{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:44:43Z","timestamp":1780465483901,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T00:00:00Z","timestamp":1739577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100018108","name":"Turner Syndrome Global Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Sex chromosome aneuploidies (SCAs) are chromosomal variations that result from an atypical number of X and\/or Y chromosomes. Combined, SCAs affect ~1\/400 live births, including individuals with Klinefelter syndrome (47, XXY), Turner syndrome (45, X and variants), Double Y syndrome (47, XYY), Trisomy X (47, XXX), and rarer tetrasomies and pentasomies. Individuals with SCAs experience a wide variety of physical health, mental health, and healthcare experiences that differ from the standard population. To understand the priorities of the SCA community we surveyed participants in two large SCA registries, the Inspiring New Science in Guiding Healthcare in Turner Syndrome (INSIGHTS) Registry and the Generating Advancements in Longitudinal Analysis in X and Y Variations (GALAXY) Registry. 303\/629 (48.1% response rate) individuals from 13 sites across the United States responded to the survey, including 251 caregivers and 52 self\u2010advocates, with a range of ages from 3\u2009weeks to 73\u2009years old, and representation from all SCA groups (Turner syndrome, XXX, XXY, XYY, XXYY, and combined rare tetrasomies and pentasomies). Results demonstrate the priorities for physical health and emotional\/behavioral health identified by the SCA community, as well as preferred types of research. All SCA subtypes indicated intervention studies as the top priority, emphasizing the need for researchers to focus on clinical treatments in response to priorities of the SCA community.<\/jats:p>","DOI":"10.1002\/ajmg.a.63998","type":"journal-article","created":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T07:30:21Z","timestamp":1739604621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Research Priorities of Individuals and Families With Sex Chromosome Aneuploidies"],"prefix":"10.1002","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1157-4554","authenticated-orcid":false,"given":"Alexandra","family":"Carl","sequence":"first","affiliation":[{"name":"eXtraOrdinarY Kids Clinic and Research Team, Children's Hospital of Colorado  Colorado Aurora 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Prakash","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Texas Health Science Center at Houston  Houston Washington, DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Strang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neuropsychology Children's National Hospital  Washington, DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"eXtraOrdinarY Kids Clinic and Research Team, Children's Hospital of Colorado  Colorado Aurora USA"},{"name":"Division of Developmental Pediatrics, Department of Pediatrics University of Colorado School of Medicine  Colorado Aurora USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Raznahan","sequence":"additional","affiliation":[{"name":"Section on Developmental Neurogenomics, Human Genetics Branch National Institute of Mental Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Endocrinology Nemours\/Alfred I. duPont Hospital for Children  Wilmington Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"INSIGHTS Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"GALAXY 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