{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T01:56:20Z","timestamp":1755222980532,"version":"3.43.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["U01DD001224"],"award-info":[{"award-number":["U01DD001224"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Finding abnormalities in a fetus by prenatal testing during pregnancy is a common reason why parents choose to terminate a pregnancy. A malformations surveillance program of all births at a tertiary center in Boston was used to identify each elective termination because of a malformation detected prenatally. A severity scale of malformations was used: lethal (anencephaly), severe\u2010handicapping (Down syndrome; myelomeningocele), moderate\u2010fixable (omphalocele) and mild (postaxial polydactyly, type B). Demographic characteristics and the findings in prenatal testing were recorded. Six hundred and sixty\u2010nine elective terminations because of fetal abnormalities were identified. A destructive procedure (dilation and evacuation; D&amp;E) was the primary method used to end the pregnancy. The gestational age at the time of termination was 18 to 19\u2009weeks. The two most common sequences of events were: (1) imaging by ultrasound established the diagnosis; (2) imaging by ultrasound led to amniocentesis which established the diagnosis. Ninety\u2010four percent of the abnormalities were either lethal or severe\u2010handicapping. The discovery of a fetal abnormality was a surprise to 98% of the parents. Single women differed from married women in being younger, less well\u2010educated, less likely to have health insurance, and more likely to terminate a pregnancy with moderate\u2010fixable malformations.<\/jats:p>","DOI":"10.1002\/ajmg.a.64051","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T01:03:52Z","timestamp":1745283832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elective Terminations Because of Fetal Abnormalities: Findings in A Tertiary Maternity Center Over 41\u2009Years (1972\u20132012)"],"prefix":"10.1002","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0259-4848","authenticated-orcid":false,"given":"Lewis B.","family":"Holmes","sequence":"first","affiliation":[{"name":"Medical Genetics and Metabolism Unit Mass General for Children  Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamzeh","family":"Nasri","sequence":"additional","affiliation":[{"name":"Medical Genetics and Metabolism Unit Mass General for Children  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Therese","family":"Hunt","sequence":"additional","affiliation":[{"name":"Hunt Consulting  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2388-2670","authenticated-orcid":false,"given":"Hanah Z.","family":"Nasri","sequence":"additional","affiliation":[{"name":"Medical Genetics and Metabolism Unit Mass General for Children  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198804213181607"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.12.034"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20350"},{"key":"e_1_2_9_5_1","first-page":"1","article-title":"Surveillance for Anencephaly and Spina Bifida and the Impact of Prenatal Diagnosis\u2014United States, 1985\u20101994","volume":"44","author":"Cragan J. 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