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This qualitative study aimed to explore the domains that were important to the oral health\u2010related quality of life in individuals with Rett syndrome (RTT). In 2021, following purposive sampling, recorded interviews were conducted with parents of individuals with a confirmed <jats:italic>MECP2<\/jats:italic> mutation in the Australian RTT database (<jats:italic>n<\/jats:italic>\u2009=\u200931). Interview questions covered experiences of oral problems, the impacts of their daughter's oral health on other aspects of her life and on the lives of others, and on the family's quality of life. Directed content analysis was conducted. Seven domains were identified around the impacts of oral health on the child\u2010 discomfort, pain, eating, activities of daily living, emotional well\u2010being, social well\u2010being, and provision of services\u2010 affecting impacts on the patient. Five domains related to impacts on the family\u2010 emotions, activities, family function, conflict, and morale and self\u2010efficacy to facilitate oral healthcare. The findings of this study pave the way for developing targeted OHRQOL measures for patients with RTT to understand and measure oral health impacts.<\/jats:p>","DOI":"10.1002\/ajmg.a.64104","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T06:19:04Z","timestamp":1745907544000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring Oral Health Related Quality of Life in Rett Syndrome Using Directed Content Analysis"],"prefix":"10.1002","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9737-1294","authenticated-orcid":false,"given":"Yvonne Yee Lok","family":"Lai","sequence":"first","affiliation":[{"name":"The University of Queensland School of Dentistry, UQ Oral Health Centre  Herston Queensland Australia"},{"name":"Telethon Kids Institute  West Perth Western Australia Australia"},{"name":"Department of Pediatric Dentistry Women's and Children's Hospital  Adelaide Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7358-9037","authenticated-orcid":false,"given":"Jenny Anne","family":"Downs","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute  West Perth Western Australia Australia"},{"name":"Curtin School of Allied Health Curtin University  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen Margaret","family":"Leonard","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute  West Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence James","family":"Walsh","sequence":"additional","affiliation":[{"name":"The University of Queensland School of Dentistry, UQ Oral Health Centre  Herston Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sobia","family":"Zafar","sequence":"additional","affiliation":[{"name":"The University of Queensland School of Dentistry, UQ Oral Health Centre  Herston Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"volume-title":"The Development and Testing of an Oral Health\u2010Related Quality of Life Measure for Children\/Adolescents With Down Syndrome (OH\u2010QOLADS)","year":"2015","author":"Aljameel A. 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