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Also, different maxillary and mandibular malformations are associated with NF1. In this retrospective register\u2010based study, we evaluated hospital visits related to dentofacial malocclusion in 1349 individuals with NF1, 13,870 matched controls and 1894 non\u2010NF1 siblings followed up over 1998\u20132014 using the Finnish Care Register for Health Care that covers information on inpatient care and specialist outpatient care. Hazard ratios (HRs) and their 95% confidence intervals (CI) were estimated with the Cox proportional hazards model. Individuals with NF1 had a higher hazard for hospital visits related to embedded and impacted teeth (HR 2.1, 95% CI 1.2\u20133.5), disorders of tooth development and eruption (HR 3.7, 95% CI 1.9\u20137.1), and dentofacial anomalies (HR 2.7, 95% CI 1.9\u20133.8) such as anomalies in dental arch relationship (HR 4.8, 95% CI 2.9\u20137.9) and anomalies of jaw\u2010cranial base relationship (HR 2.2, 95% CI 1.1\u20134.3) compared with controls. Plexiform neurofibromas did not markedly affect the estimates. Early detection of jaw and dental alterations, which may be linked to previously identified cephalometric features of NF1, is important for preventing occlusal defects, maintaining oral hygiene, and preserving quality of life.<\/jats:p>","DOI":"10.1002\/ajmg.a.64110","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T06:20:32Z","timestamp":1747117232000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dentofacial Malocclusion in Neurofibromatosis 1 in Finland"],"prefix":"10.1002","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2313-8099","authenticated-orcid":false,"given":"Vivian","family":"Reinhold","sequence":"first","affiliation":[{"name":"Cancer Research Unit Institute of Biomedicine, University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Valtanen","sequence":"additional","affiliation":[{"name":"Cancer Research Unit Institute of Biomedicine, University of Turku  Turku Finland"},{"name":"Department of Mathematics and Statistics University of Turku  Turku Finland"},{"name":"Department of Public Health Finnish Institute for Health and Welfare  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kari","family":"Auranen","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics University of Turku  Turku Finland"},{"name":"Department of Clinical Medicine University of Turku  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0738-5698","authenticated-orcid":false,"given":"Stina","family":"Syrj\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Institute of Dentistry, University of Turku  Turku Finland"},{"name":"Department of Pathology Turku University Hospital  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0990-1430","authenticated-orcid":false,"given":"Sirkku","family":"Peltonen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology University of Helsinki  Helsinki Finland"},{"name":"Skin and Allergy Hospital Helsinki University Hospital  Helsinki Finland"},{"name":"Department of Dermatology and Venereology University of Turku  Turku Finland"},{"name":"Department of Dermatology Turku University Hospital  Turku Finland"},{"name":"Department of Dermatology and Venereology Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5732-4167","authenticated-orcid":false,"given":"Juha","family":"Peltonen","sequence":"additional","affiliation":[{"name":"Cancer Research Unit Institute of Biomedicine, University of Turku  Turku Finland"},{"name":"FICAN West Cancer Centre University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7512-2980","authenticated-orcid":false,"given":"Roope A.","family":"Kallionp\u00e4\u00e4","sequence":"additional","affiliation":[{"name":"Cancer Research Unit Institute of Biomedicine, University of Turku  Turku Finland"},{"name":"Department of Dermatology and Venereology Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"FICAN West Cancer Centre University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"volume-title":"Wheeler's Dental Anatomy, Physiology, and Occlusion","year":"2003","author":"Ash M. 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