{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:29:15Z","timestamp":1788881355098,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sotos syndrome is an autosomal dominant condition caused by pathogenic variants in the\n                    <jats:italic>NSD1<\/jats:italic>\n                    gene on chromosome 5q35. It is characterized by macrosomia, distinctive facial features, and developmental delays. Patients are also reported to have a behavioral phenotype including autism spectrum disorder, attention deficit\/hyperactivity disorder, anxiety, and increased rates of tantrums and aggressive behavior. Here, we introduce and phenotype a novel cohort of 25 patients with molecularly confirmed Sotos syndrome. We also present the detailed behavioral histories of two patients and provide guidance for managing the behavioral manifestations of Sotos syndrome, highlighting the importance of a multidisciplinary approach to care for patients with this complex overgrowth condition.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.a.64129","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T09:19:37Z","timestamp":1750843177000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Behavioral Phenotype and Importance of Multidisciplinary Care in Patients With Sotos Syndrome: A Single\u2010Center Experience"],"prefix":"10.1002","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8127-3419","authenticated-orcid":false,"given":"Aravind","family":"Viswanathan","sequence":"first","affiliation":[{"name":"Division of Human Genetics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6661-3924","authenticated-orcid":false,"given":"Andrew M.","family":"George","sequence":"additional","affiliation":[{"name":"Division of Human Genetics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4399-0644","authenticated-orcid":false,"given":"Evan R.","family":"Hathaway","sequence":"additional","affiliation":[{"name":"Division of Human Genetics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlyn","family":"Glatts","sequence":"additional","affiliation":[{"name":"Division of Development and Behavioral Pediatrics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1500-9713","authenticated-orcid":false,"given":"Jennifer M.","family":"Kalish","sequence":"additional","affiliation":[{"name":"Division of Human Genetics Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Departments of Pediatrics and Genetics Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Center for Childhood Cancer Research Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426\u2010200403000\u201000013"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsab132"},{"key":"e_1_2_14_4_1","unstructured":"Balasundaram P. andI. 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