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In 14 patients with\n                    <jats:styled-content style=\"fixed-case\">ATS<\/jats:styled-content>\n                    , aortic and pulmonary artery longitudinal growth, phenotypes, and interventions were evaluated. Medical records and images of 14 patients with\n                    <jats:styled-content style=\"fixed-case\">ATS<\/jats:styled-content>\n                    (defined as biallelic\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>SLC2A10<\/jats:italic>\n                    <\/jats:styled-content>\n                    variants with consistent phenotypes) were reviewed. Vascular measurements were collected from imaging reports. Z\u2010scores were calculated. Dilation and hypoplasia were defined as z\u2010scores \u2265 +2.0 and \u2264 \u22122.0, respectively. Slopes were calculated using mixed linear regression. Our cohort consisted of 9 males (64%). Median diagnosis age was 3.3\u2009years; median follow up duration was 5.7\u2009years. By echocardiography, aortic root dilation was present in 71.4%; branch pulmonary artery (\n                    <jats:styled-content style=\"fixed-case\">BPA<\/jats:styled-content>\n                    ) dimensions were mixed between dilated and hypoplastic. By echocardiography and cross\u2010sectional imaging, aortic and\n                    <jats:styled-content style=\"fixed-case\">BPA<\/jats:styled-content>\n                    dimensions increased over time but had stable z\u2010scores. Three patients underwent repeated\n                    <jats:styled-content style=\"fixed-case\">BPA<\/jats:styled-content>\n                    interventions, one patient had an aortopexy, and one patient had an aortic valve replacement. No patients had arterial dissections. Six new variants are described. In conclusion, aortic dilation is usual and persists in\n                    <jats:styled-content style=\"fixed-case\">ATS<\/jats:styled-content>\n                    with stable z\u2010scores similar to other aortopathies.\n                    <jats:styled-content style=\"fixed-case\">BPA<\/jats:styled-content>\n                    stenosis is a common complication in\n                    <jats:styled-content style=\"fixed-case\">ATS<\/jats:styled-content>\n                    leading to invasive vascular procedures.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.a.64159","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T08:06:00Z","timestamp":1751616360000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Arterial Tortuosity Syndrome: A Longitudinal Assessment of Cardiovascular Features and Interventions From the Collaborative for Longitudinal Aortic Research in the Young (CLARITY)"],"prefix":"10.1002","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7166-0669","authenticated-orcid":false,"given":"Bita","family":"Salamat","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics Texas Children's Hospital and Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2180-2198","authenticated-orcid":false,"given":"Sara B.","family":"Stephens","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics Texas Children's Hospital and Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Epidemiology, Human Genetics and Environmental Sciences School of Public Health, University of Texas Health Science Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolie 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