{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T02:26:03Z","timestamp":1766975163132,"version":"3.48.0"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01 HG010903"],"award-info":[{"award-number":["K01 HG010903"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Despite the growing availability of consumer genetic testing for serious disease risks, outcomes data remain limited for individuals undergoing testing for high\u2010 and moderate\u2010penetrance genes. To address this gap, we evaluated the feasibility of the Consumer Genetic Testing Outcomes Evaluation Paradigm (CGT\u2010OEP), a novel approach for studying cognitive, affective, and behavioral outcomes in individuals pursuing physician\u2010mediated genetic testing. We recruited participants to purchase Color Health's genetic test for cancer and cardiovascular disease risk. Participants completed Baseline (T0), Pre\u2010Disclosure (T1), and Two\u2010Week Post\u2010Disclosure (T2) surveys and shared results with the study team. Of 185 consented participants, 105 (56.8%) purchased tests, with 103 (98.1%) completing all requirements. Purchasers were predominantly white (89%), female (73%), and college\u2010educated (80%). Participants reported high satisfaction and minimal negative emotions, uncertainty, or decisional regret; most (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200967, 65%) planned to share results with providers. Although genetic knowledge increased and anxiety decreased post\u2010disclosure, many participants misinterpreted negative and VUS results as indicating lower\u2010than\u2010average risk for cancer (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200941, 42%) and cardiovascular disease (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200945, 46%). Our findings demonstrate that the CGT\u2010OEP is a feasible, effective approach for studying consumer genetic testing. While participants reported positive experiences, findings highlight concerns about result comprehension and potential false reassurance, particularly for negative\/VUS results.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.a.64169","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T12:14:26Z","timestamp":1753791266000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes from a Novel Approach to Studying Consumer Genetic Testing for Germline Cancer and Cardiovascular Risk"],"prefix":"10.1002","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8923-9944","authenticated-orcid":false,"given":"Madison K.","family":"Kilbride","sequence":"first","affiliation":[{"name":"Department of Philosophy University of Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Chavez\u2010Yenter","sequence":"additional","affiliation":[{"name":"Department of Medical Ethics and Health Policy University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Division of Hematology\u2010Oncology, Abramson Cancer Center University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bob","family":"Wong","sequence":"additional","affiliation":[{"name":"College of Nursing, University of Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1083-8299","authenticated-orcid":false,"given":"J. Scott","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Health Behavior &amp; Health Equity, School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Park","sequence":"additional","affiliation":[{"name":"College of Engineering, University of Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Iuliano","sequence":"additional","affiliation":[{"name":"S.J. Quinney College of Law, University of Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela R.","family":"Bradbury","sequence":"additional","affiliation":[{"name":"Department of Medical Ethics and Health Policy University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Division of Hematology\u2010Oncology, Abramson Cancer Center University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2017.11.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.192"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2007.02.007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20103999(01)00296\u20103"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.85"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.66.3450"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X03256005"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073\u2010014\u20100096\u20100"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.34"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606\u2010008\u20100520\u20105"},{"key":"e_1_2_9_12_1","unstructured":"Color Health.2025.\u201cColor Genomics Product Overview.\u201dhttps:\/\/www.color.com\/product\/overview."},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2019.11.003"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.46.9403"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gim.0000250197.44245.a3"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689\u2010004\u20107995\u2010y"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.1503"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.26"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2014.0128"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACM.0b013e31823ab7d2"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.9.081307.164319"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40615\u2010023\u201001526\u20104"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842\u2010197905000\u201000004"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.04.009"},{"issue":"4","key":"e_1_2_9_25_1","first-page":"84","article-title":"A Systematic Review of Strategies That Increase the Recruitment and Retention of African American Adults in Genetic and Genomic Studies","volume":"22","author":"Johnson V. 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