{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:51:49Z","timestamp":1791273109242,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["NIH\/NICHD R03HD102773"],"award-info":[{"award-number":["NIH\/NICHD R03HD102773"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Individuals with Turner syndrome (TS) are known to be at increased risk for neurodevelopmental disorders (NDD) and mental health (MH) conditions, but data from large, population\u2010based pediatric samples remain limited. We examined the prevalence of NDD and MH diagnoses among youth with TS (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u20092145) compared to matched female controls (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u20098580) across six US pediatric health systems. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using generalized estimating equations. Youth with TS had significantly higher odds of an NDD diagnosis (24.2% vs. 11.9%; OR 2.37, 95% CI 2.11\u20132.67), particularly for speech\u2010language, motor, learning, and attentional disorders. Increased odds were also observed for autism spectrum disorder (ASD) and intellectual developmental disorder (IDD), though these remained relatively uncommon. In contrast, MH diagnoses, such as anxiety and mood disorders, were not more prevalent in TS compared to controls (17.3% vs. 18.5%; OR 0.92, 95% CI 0.81\u20131.05). These findings support the need for proactive neurodevelopmental screening in TS and raise important questions about the recognition and documentation of MH conditions in this population. Additional research is warranted to understand whether MH symptoms are underdiagnosed, present differently, or emerge later in development in youth with TS.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.a.64231","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T12:22:51Z","timestamp":1757938971000},"page":"308-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neurodevelopmental and Mental Health Diagnoses Among Pediatric Patients With Turner Syndrome: A\n                    <scp>PEDSnet<\/scp>\n                    Study"],"prefix":"10.1002","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4591-1025","authenticated-orcid":false,"given":"Christa","family":"Hutaff\u2010Lee","sequence":"first","affiliation":[{"name":"University of Colorado Anschutz Medical Campus  Aurora Colorado USA"},{"name":"Department of Pediatrics Children's Hospital Colorado  Aurora 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Hospital  Columbus Ohio USA"},{"name":"Department of Pediatrics The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0630-2355","authenticated-orcid":false,"given":"Chijioke","family":"Ikomi","sequence":"additional","affiliation":[{"name":"Nemours Children's Health  Wilmington Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4747-6949","authenticated-orcid":false,"given":"Vaneeta","family":"Bamba","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5179-0282","authenticated-orcid":false,"given":"Rachel E.","family":"Lean","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Washington University School of Medicine  St. 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