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Here, anthropometric measures of adiposity, basal metabolic requirements, and fasted blood samples were obtained from adults with restricted growth (age 41\u2009\u00b1\u200914\u2009years, height 1.30\u2009\u00b1\u20090.10\u2009m, body mass 60.5\u2009\u00b1\u200918.3\u2009kg, female: male\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200924:13, achondroplasia\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200926; mean\u2009\u00b1\u2009SD). Basal metabolic rate was 6529\u2009\u00b1\u20091703\u2009kJ\u00b7d\n                    <jats:sup>\u22121<\/jats:sup>\n                    and total mass\u2010normalized energy requirements were higher for females versus males. Plasma concentrations of glucose (5.55\u2009\u00b1\u20090.73\u2009mmol\u00b7L\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), insulin (36.4\u2009\u00b1\u200919.9\u2009pmol\u00b7L\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) and lipids (triacylglycerol 0.84\u2009\u00b1\u20090.37\u2009mmol\u00b7L\n                    <jats:sup>\u22121<\/jats:sup>\n                    ; total cholesterol 4.54\u2009\u00b1\u20090.85\u2009mmol\u00b7L\n                    <jats:sup>\u22121<\/jats:sup>\n                    ; high\u2010density lipoprotein cholesterol 1.41\u2009\u00b1\u20090.31\u2009mmol\u00b7L\n                    <jats:sup>\u22121<\/jats:sup>\n                    ; low\u2010density lipoprotein cholesterol 2.73\u2009\u00b1\u20090.69\u2009mmol\u00b7L\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) were mostly within healthy clinical reference ranges. Sagittal abdominal diameter was positively correlated with plasma glucose and leptin concentrations (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.85; 95% CI: 0.61, 0.95;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001, and\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.85; 95% CI: 0.61, 0.95;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001, respectively). Mean\u2009\u00b1\u2009SD body mass index (BMI) was 36.1\u2009\u00b1\u200911.0\u2009kg\u00b7m\n                    <jats:sup>\u22122<\/jats:sup>\n                    . However, we found that body mass scaled to height by the power of 1.4 (95% CI: 0.2, 2.6) rather than 2 associated with conventional BMI. Conventional biomarkers of cardiometabolic health are not substantially elevated in these individuals with restricted growth despite the classification of obesity using height\u2010dependent references (e.g., traditional BMI).\n                  <\/jats:p>","DOI":"10.1002\/ajmg.a.64235","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T02:34:09Z","timestamp":1757644449000},"page":"144-154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Basal Metabolic Requirements, Biomarkers of Cardiometabolic Health, and Anthropometric Measures of Obesity in Women and Men With Restricted Growth Conditions"],"prefix":"10.1002","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7946-8201","authenticated-orcid":false,"given":"Lucy H.","family":"Merrell","sequence":"first","affiliation":[{"name":"Centre for Nutrition, Exercise and Metabolism (CNEM), Department for Health University 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