{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:46:35Z","timestamp":1785836795071,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["JP24K10739"],"award-info":[{"award-number":["JP24K10739"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Irritability is a core challenge in Prader\u2013Willi syndrome (PWS). This study investigated the independent contribution of sensory processing to irritability while controlling for clinical and genetic backgrounds in a cohort of 101 individuals with PWS (77 deletion, 24 maternal uniparental disomy [mUPD]). Caregivers completed the Japanese version of the Short Sensory Profile (SSP\u2010J) and the irritability subscale of the Aberrant Behavior Checklist (ABC\u2010J). Hierarchical multiple regression analysis was performed. In Step 1, age, sex, genetic subtype, and psychotropic medication use explained 22.3% of irritability variance (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.223,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Adding sensory variables in Step 2 explained an additional 38.2% (\u0394\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.382,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), totaling 60.6% (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2009=\u20090.606). Auditory filtering (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.262), under\u2010responsiveness\/seeking sensation (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.201), and visual\/auditory sensitivity (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2009=\u20090.194) were significant independent predictors (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Notably, the effect of the mUPD subtype became non\u2010significant after accounting for sensory variables. Sensory processing is a robust predictor of irritability, independent of genetic subtype and medication. Evaluating sensory profiles is essential for environmental adaptations and behavioral interventions in PWS.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.a.70184","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:58:57Z","timestamp":1777456737000},"page":"2061-2066","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations Between Sensory Processing and Irritability in Prader\u2013Willi Syndrome: Beyond Genetic Subtypes and Clinical Backgrounds"],"prefix":"10.1002","volume":"200","author":[{"given":"Erina","family":"Nakane","sequence":"first","affiliation":[{"name":"Department of Psychiatry Dokkyo Medical University Saitama Medical Center  Koshigaya Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Dokkyo Medical University Saitama Medical Center  Koshigaya Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohei","family":"Saima","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Dokkyo Medical University Saitama Medical Center  Koshigaya Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuichi","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Ikezawa Shinkeika Hospital  Hanyuu Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7654-0085","authenticated-orcid":false,"given":"Masaki","family":"Seki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Okute Hospital  Mizunami Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0130-0585","authenticated-orcid":false,"given":"Yuji","family":"Oto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dokkyo Medical University Saitama Medical Center  Koshigaya Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ihara","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Dokkyo Medical University Saitama Medical Center  Koshigaya Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Aberrant Behavior Checklist: Manual","author":"Aman M. 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