{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:50:45Z","timestamp":1791561045288,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Prader\u2013Willi syndrome (PWS) is a rare neurogenetic disorder characterized by endocrine, metabolic, behavioral, and psychiatric features. These manifestations may affect health\u2010related quality of life (HRQOL). Evidence on HRQOL in adolescents and adults with PWS remains limited. This study evaluated HRQOL and examined sex, age, genetic, and behavioral factors associated with HRQOL in individuals with genetically confirmed PWS aged 16\u2009years and over. A proxy\u2010reported questionnaire survey was conducted through a Japanese national PWS support group, and responses from 119 participants (median age, 25\u2009years) were analyzed. The primary outcome was a EuroQol five\u2010dimension five\u2010level (EQ\u20105D\u20105L) index value in the upper tertile of the study distribution (\u2265\u20090.744). The median EQ\u20105D\u20105L index value was 0.665 (IQR, 0.549\u20130.775), and the mean was 0.652 (SD, 0.180). Only 4.3% of participants reported no problems in any dimension. Younger age (16\u201319\u2009years) (OR, 4.62; 95% CI, 1.42\u201315.1), the deletion genetic subtype (4.79; 1.15\u201320.0), and lower problematic food\u2010related behaviors (0.90; 0.83\u20130.97) were independently associated with an EQ\u20105D\u20105L index value in the upper tertile. Support during the transition from late adolescence to early adulthood and attention to problematic food\u2010related behaviors may be important for improving the HRQOL of individuals with PWS.<\/jats:p>","DOI":"10.1002\/ajmg.a.70222","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T03:55:16Z","timestamp":1780286116000},"page":"2464-2471","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Health\u2010Related Quality of Life and Its Related Factors in Adolescents and Adults With Prader\u2013Willi Syndrome in Japan"],"prefix":"10.1002","volume":"200","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8135-055X","authenticated-orcid":false,"given":"Ayako","family":"Konishi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Nutrition, and Endocrinology Osaka Women's and Children's Hospital  Izumi Japan"},{"name":"Department of Public Health Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Tachibana","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Osaka University  Suita Japan"},{"name":"Research Committee on Clinical Management of Growth Disorders and Differences of Sex Development, Research on Measures for Intractable Diseases, Health and Labour Sciences Research Grants  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0130-0585","authenticated-orcid":false,"given":"Yuji","family":"Oto","sequence":"additional","affiliation":[{"name":"Research Committee on Clinical Management of Growth Disorders and Differences of Sex Development, Research on Measures for Intractable Diseases, Health and Labour Sciences Research Grants  Tokyo Japan"},{"name":"Department of Pediatrics Dokkyo Medical University Saitama Medical Center  Koshigaya 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