{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T06:01:40Z","timestamp":1784959300685,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["American J of Med Genetics Pt A"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Dengue virus (DENV) poses a serious global health challenge, particularly in cases of dengue hemorrhagic fever (DHF). Patients with preexisting mitochondrial disorders may be at increased risk for complications due to the specific impact of DENV on mitochondrial\u2010dependent cellular processes and immune function. We describe a 16\u2010year\u2010old male with known mitochondrial complex I deficiency caused by a homozygous likely pathogenic variant in\n                    <jats:italic>NDUFV1<\/jats:italic>\n                    who subsequently developed DHF. His illness was marked by rapidly worsening weakness, respiratory distress, intracranial hemorrhage, and seizures. His clinical course was further complicated by encephalitis, arachnoiditis, and myelitis requiring extensive immunomodulation. He received corticosteroids, intravenous immunoglobulin (IVIG), and plasma exchange (PLEX), which led to improvement and partial recovery of functional status. This case highlights several rare complications of dengue fever, the impact of DENV on mitochondrial function,\u00a0and underscores the complexity of managing infectious diseases in individuals with underlying mitochondrial disorders.\n                  <\/jats:p>","DOI":"10.1002\/ajmg.a.70258","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:42:21Z","timestamp":1784958141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immune Modulatory Therapy for Severe Dengue Hemorrhagic Fever in a Patient With Mitochondrial Complex I Deficiency: A Case Report"],"prefix":"10.1002","author":[{"given":"Audra N.","family":"Iness","sequence":"first","affiliation":[{"name":"Department of Molecular and Human Genetics Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3248-0761","authenticated-orcid":false,"given":"Ameya S.","family":"Walimbe","sequence":"additional","affiliation":[{"name":"Texas Children's Hospital  Houston Texas USA"},{"name":"Division of Pediatric Neurology and Developmental Neuroscience, Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily R.","family":"Strouphauer","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Hirano","sequence":"additional","affiliation":[{"name":"Neuromuscular Medicine Division Columbia University Irving Medical Center, H. Houston Merritt Center for Muscular Dystrophy and Related Diseases  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro D.","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Pediatrics at New York Presbyterian Hospital Columbia University Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Emmanuele","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin C.","family":"Griffin","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics, Department of Pediatrics at New York Presbyterian Hospital Columbia University Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheldon L.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Texas Children's Hospital  Houston Texas USA"},{"name":"Division of Infectious Diseases, Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Department of Radiology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen K.","family":"Moeller","sequence":"additional","affiliation":[{"name":"Department of Radiology Baylor College of Medicine  Houston Texas USA"},{"name":"Division of Neuroradiology, Edward B. Singleton Department of Radiology Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen F.","family":"Kralik","sequence":"additional","affiliation":[{"name":"Department of Radiology Baylor College of Medicine  Houston Texas USA"},{"name":"Division of Neuroradiology, Edward B. Singleton Department of Radiology Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3502-8460","authenticated-orcid":false,"given":"Fernando","family":"Scaglia","sequence":"additional","affiliation":[{"name":"Department of Molecular and Human Genetics Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Hospital  Houston Texas USA"},{"name":"Joint BCM\u2010CUHK Center of Medical Genetics, Prince of Wales Hospital  Hong Kong SAR China"},{"name":"Baylor Genetics  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"issue":"18","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"8968","DOI":"10.3390\/ijms26188968","article-title":"The Impacts of Dengue Virus Infection on Mitochondrial Functions and Dynamics","volume":"26","author":"Ahmed S.","year":"2025","journal-title":"International Journal of Molecular Sciences"},{"issue":"8","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002373","article-title":"Serum Metabolome and Lipidome Changes in Adult Patients With Primary Dengue Infection","volume":"7","author":"Cui L.","year":"2013","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pediatrneurol.2015.12.010","article-title":"Mitochondrial Encephalomyopathy Lactic Acidosis and Stroke\u2010Like Episodes (MELAS): A Case Report and Critical Reappraisal of Treatment Options","volume":"56","author":"Fryer R. 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