{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:43:03Z","timestamp":1790462583427,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,3,14]],"date-time":"2003-03-14T00:00:00Z","timestamp":1047600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2003,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several independent genome scans have revealed excess allele sharing in an overlapping 40 cM region of 7q21\u201034 in autism. DLX6 and Piccolo (PCLO) at 7q21\u2010q22 are two positional and functional candidate genes in autism. We have investigated a single nucleotide polymorphism (SNP) in exon 4 of the PCLO gene and a SNP in intron 1 of the DLX6 gene for linkage and association in autistic disorder using both qualitative and quantitative analyses. One hundred ninety\u2010six multiplex autistic disorder families were tested using transmission disequilibrium and two\u2010point affected sib pair linkage analysis. We found no evidence of association or linkage with the two intragenic markers. In addition, there was also no linkage or association between language and stereotypic behavior quantitative traits in autism and the SNPs. In conclusion, our studies suggest that these two SNPs in DLX6 and PCLO genes are not in linkage disequilibrium with autism. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.10012","type":"journal-article","created":{"date-parts":[[2003,4,17]],"date-time":"2003-04-17T10:02:02Z","timestamp":1050573722000},"page":"98-101","source":"Crossref","is-referenced-by-count":14,"title":["No association between single nucleotide polymorphisms in DLX6 and piccolo genes at 7q21\u2010q22 and autism"],"prefix":"10.1002","volume":"119B","author":[{"given":"Rafiqun","family":"Nabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatema J","family":"Serajee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AHM Mahbubul","family":"Huq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,3,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/302698"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/316944"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng786"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/338241"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700028099"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/340364"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/088307389601100509"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80883-1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/35103559"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1977.tb00443.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/321292"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2272(1996)13:2<117::AID-GEPI1>3.0.CO;2-5"},{"key":"e_1_2_7_14_1","first-page":"1347","article-title":"Parametric and nonparametric linkage analysis: A unified multipoint approach","volume":"58","author":"Kruglyak L","year":"1996","journal-title":"Am J Hum Genet"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199712)210:4<498::AID-AJA12>3.0.CO;2-3"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/301904"},{"key":"e_1_2_7_17_1","first-page":"1293","article-title":"The coding region of the human DLX6 gene contains a polymorphic CAG\/CCG repeat","volume":"18","author":"Pfeffer U","year":"2001","journal-title":"Int J Oncol"},{"key":"e_1_2_7_18_1","first-page":"717","article-title":"Latent\u2010class analysis of recurrence risks for complex phenotypes with selection and measurement error: A twin and family history study of autism","volume":"57","author":"Pickles A","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/302497"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10048"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.6.2250"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.10012","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.10012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T15:25:00Z","timestamp":1697037900000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.10012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3,14]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,5,15]]}},"alternative-id":["10.1002\/ajmg.b.10012"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.10012","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3,14]]}}}