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Elastin is a prominent component of mitral valves and, in a genome screen of 23 pedigrees with PD, we found evidence of linkage to the region of chromosome 7 that contains the elastin gene (<jats:italic>ELN<\/jats:italic>). Therefore, we examined the minimal essential promoter and coding regions of <jats:italic>ELN<\/jats:italic> in 23 independent probands from the families in our linkage studies using single strand conformational polymorphism analysis. We found three polymorphisms including one that coded for a non\u2010conservative amino acid change. However, none of these polymorphisms were associated with panic disorder in a case\u2010control analysis or linked to it in multiplex pedigrees. In our pedigrees, exonic polymorphisms in <jats:italic>ELN<\/jats:italic> do not play a major role in the genetic vulnerability to PD. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.10014","type":"journal-article","created":{"date-parts":[[2003,1,29]],"date-time":"2003-01-29T15:36:34Z","timestamp":1043854594000},"page":"7-10","source":"Crossref","is-referenced-by-count":8,"title":["Role of elastin polymorphisms in panic disorder"],"prefix":"10.1002","volume":"117B","author":[{"given":"Robert A.","family":"Philibert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Bedell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhinda","family":"Goedken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harinder K.","family":"Sandhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Russell","family":"Noyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond R.","family":"Crowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,10,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/79216"},{"key":"e_1_2_6_3_1","volume-title":"Diagnostic and statistical manual of mental disorder, (third edition, revised)","author":"American Psychiatric Association","year":"1987"},{"key":"e_1_2_6_4_1","volume-title":"Diagnostic and statistical manual of mental disorder, (fourth edition)","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-029090"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20010108)105:1<105::AID-AJMG1072>3.0.CO;2-P"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199309000-00002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960726)67:4<401::AID-AJMG14>3.0.CO;2-N"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.155.11.1578"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004390051084"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20010108)105:1<130::AID-AJMG1076>3.3.CO;2-G"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1995.0349"},{"key":"e_1_2_6_13_1","unstructured":"RozenS SkaletskyH.1997.Primer 3. 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