{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T22:51:27Z","timestamp":1762210287456},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study is a continuation and extension of the work with Orton Developmental Dyslexia (DD) pedigrees [Grigorenko et al., <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib16\">1997<\/jats:ext-link>; <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib17\">2000<\/jats:ext-link>, Grigorenko et al., <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib18\">2001<\/jats:ext-link>]. This study utilized an extended sample (<jats:italic>N<\/jats:italic>\u2009=\u2009176) and a well\u2010saturated map of chromosome 6p (30 markers). Six phenotypes were constructed to span a range of dyslexia\u2010related cognitive processes. These phenotypes were: (1) Phonemic Awareness (of spoken words); (2) Phonological Decoding (of printed nonwords); (3) Rapid Automatized Naming (of colored squares or object drawings); (4) Single Word Reading (orally, of printed real words); (5) Phonemic Awareness\/Decoding\/Single\u2010Word Reading pathway; and (6) Phonemic Awareness\/Rapid Naming\/Single\u2010Word Reading pathway. The study resulted in two major findings. First, considering the distributions of the genetic linkage indicators across all phenotypes examined, there appear to be three regions of interest (around markers D6S109, D6S1261, and in the D6S105\u2013D6S265 region). Any of these regions could serve as a starting point in the search for specific gene candidates contributing to the manifestation of DD, yet they all might be echo peaks of a single peak, the boundary of which is difficult to establish due to the limited power of this sample. Second, the DD\u2010related linkage in 6p21.3 appears to be most closely related to the manifestations of DD through phonemic awareness and single\u2010word reading deficits. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.10032","type":"journal-article","created":{"date-parts":[[2003,3,18]],"date-time":"2003-03-18T23:05:14Z","timestamp":1048028714000},"page":"89-98","source":"Crossref","is-referenced-by-count":32,"title":["Continuing the search for dyslexia genes on 6p"],"prefix":"10.1002","volume":"118B","author":[{"given":"Elena L.","family":"Grigorenko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank B.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Golovyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Pauls","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,11]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"AhnJ WonT\u2010W KaplanD GruenJ.2001.A multiplex panel of 29 STR markers spanning the 6p21.3\u201022 reading disability locus. 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