{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:46:13Z","timestamp":1774691173705,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,3,7]],"date-time":"2003-03-07T00:00:00Z","timestamp":1046995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"\u201cProject Cabanis\u201d, Pfizer France"},{"name":"\u201cFondation pour la recherche m\u00e9dicale, Action dynamique en Psychiatrie\u201d (D.G.)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2003,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies testing the functional polymorphism in the promoter of the serotonin\u2010transporter gene (<jats:italic>5HTTLPR<\/jats:italic>) in various psychiatric conditions have suggested that the association could be with an intermediate phenotype, impulsivity and\/or violence rather than with a diagnosis. Schizophrenia is associated with a high risk of suicide, especially in patients with high impulsivity. We examined whether this polymorphism could be associated with violent suicide and\/or impulsivity in schizophrenic patients. We genotyped the 5HTTLPR polymorphism in 185 unrelated schizophrenic patients from a French Caucasian population. The genotype frequencies significantly differed between patients who made violent suicide attempts and both, those who attempted suicide with a non\u2010violent method (<jats:italic>P<\/jats:italic>\u2009=\u20090.013) and those who never attempted suicide (<jats:italic>P<\/jats:italic>\u2009=\u20090.026). The genotypes containing the low activity \u201cshort\u201d allele was significantly more frequent in violent suicide attempters (<jats:italic>P<\/jats:italic>\u2009=\u20090.007) than in non\u2010violent suicide attempters. No evidence was found for an association either with schizophrenia itself, when compared to gender and ethnically matched controls (n\u2009=\u2009159) or with impulsivity, assessed using Barratt's Impulsivity Scale. Although replication studies are warranted, these results in schizophrenia further support the hypothesis that 5HTTLPR polymorphism is a risk factor for violent suicidal behavior. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.10037","type":"journal-article","created":{"date-parts":[[2003,4,17]],"date-time":"2003-04-17T10:02:02Z","timestamp":1050573722000},"page":"13-17","source":"Crossref","is-referenced-by-count":36,"title":["5HTTLPR polymorphism in schizophrenic patients: Further support for association with violent suicide 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