{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:32:33Z","timestamp":1759530753297},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T00:00:00Z","timestamp":1050364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2003,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The pathophysiology of polydipsia in patients with schizophrenia is inadequately understood. This study aims to investigate the genetic influence on polydipsia in schizophrenia, and is comprised of a family study and an association study. First, we screened in\u2010patients in 14 psychiatric hospitals and found a total of 36 pairs of a proband and his\/her first\u2010degree relative, both of whom were diagnosed with schizophrenia. Among these pairs, a significant familial concordance of polydipsia was found (Fisher's exact test, two\u2010sided, <jats:italic>P<\/jats:italic>\u2009=\u20090.0014; odds ratio, 88.20; 95% confidence interval, 7.31\u20131064.34). These results indicate that genetic factors may underlie the pathophysiology of polydipsia in patients with schizophrenia. Subsequently, we examined the genetic association between polydipsia\/water intoxication and the angiotensin\u2010converting enzyme (ACE) insertion (I)\/deletion (D) polymorphism in patients with chronic schizophrenia (polydipsics: n\u2009=\u200965; non\u2010polydipsics: n\u2009=\u200997) because several lines of evidence suggested that ACE might be involved in the development of polydipsia in schizophrenia. The D allele of ACE was found to be associated with a non\u2010significant trend toward an increased risk of polydipsia (<jats:italic>P<\/jats:italic>\u2009=\u20090.086). Furthermore, a significant allelic association was found between the D allele of ACE and water intoxication (<jats:italic>P<\/jats:italic>\u2009=\u20090.0392). This significance remained after the data were adjusted for confounding variables by regression analysis. These results suggest that the ACE D allele may be a risk factor for polydipsia\/water intoxication in patients with schizophrenia. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.10066","type":"journal-article","created":{"date-parts":[[2003,4,17]],"date-time":"2003-04-17T10:02:02Z","timestamp":1050573722000},"page":"7-12","source":"Crossref","is-referenced-by-count":11,"title":["Genetic approaches to polydipsia in schizophrenia: A preliminary report of a family study and an association study of an angiotensin\u2010converting enzyme gene polymorphism"],"prefix":"10.1002","volume":"119B","author":[{"given":"Takahiro","family":"Shinkai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Ohmori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Hori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,4,15]]},"reference":[{"key":"e_1_2_3_2_1","first-page":"55","article-title":"Somatic findings in patients with psychogenic polydipsia","volume":"44","author":"Blum A","year":"1983","journal-title":"J Clin 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