{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T19:46:48Z","timestamp":1762112808998},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,11,27]],"date-time":"2002-11-27T00:00:00Z","timestamp":1038355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Apolipoprotein D (APOD, gene; apoD, protein) is involved in neuroregenerative and neurodegenerative processes, and is upregulated in late\u2010onset Alzheimer disease (AD) patients compared to nondemented controls. No genetic association studies have yet been carried out to investigate the role of APOD in AD. We have reported recently several sequence variants in the APOD gene, which are present exclusively among African blacks. In the present study we examined the role of four APOD genetic variants (Intron 1, codons 36, 108, 158) in modifying the risk of AD in 70 subjects with AD and 163 nondemented subjects from a population\u2010based African\u2010American cohort in Indianapolis. The <jats:italic>Intron 1*2<\/jats:italic> allele was associated with an increased AD risk with an age, gender and APOE adjusted odds ratio (OR) of 2.29 (95% confidence interval [CI]: 1.19\u20134.43; <jats:italic>P<\/jats:italic>\u2009=\u20090.013), and this risk was confined to <jats:italic>APOE*4<\/jats:italic> carriers (OR 3.12; 95% CI: 1.13\u20138.60; <jats:italic>P<\/jats:italic>\u2009=\u20090.028). The frequency of the codon 36\/GT genotype was non\u2010significantly higher in individuals with AD than nondemented subjects (4.3% vs. 1.2%) with an adjusted OR of 4.24 (95% CI: 0.66\u201327.14; <jats:italic>P<\/jats:italic>\u2009=\u20090.13). Our data suggest that the risk of AD among African\u2010Americans may be modified by genetic variation in APOD. Larger population\u2010based or case\u2010control studies are needed to confirm the role of APOD genetic variation in AD. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.10798","type":"journal-article","created":{"date-parts":[[2002,12,24]],"date-time":"2002-12-24T00:30:08Z","timestamp":1040689808000},"page":"98-101","source":"Crossref","is-referenced-by-count":31,"title":["Genetic variation in apolipoprotein D affects the risk of Alzheimer disease in African\u2010Americans"],"prefix":"10.1002","volume":"116B","author":[{"given":"Purnima P.","family":"Desai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh C.","family":"Hendrie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca M.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill R.","family":"Murrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven T.","family":"DeKosky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Ilyas","family":"Kamboh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,11,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.1054"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"17805","DOI":"10.1016\/S0021-9258(18)38235-8","article-title":"Accumulation of apolipoproteins in the regenerating and remyelinating mammalian peripheral nerve: identification of apolipoprotein D, apolipoprotein A\u2010IV, apolipoprotein E, and apolipoprotein A\u2010I","volume":"265","author":"Boyles JK","year":"1990","journal-title":"J Biol Chem"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8346443"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(02)00012-6"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1987.6.199"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550160069041"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0731615.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.4.594"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.152.10.1485"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.9.1663"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2307\/1390807"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.32.1.461"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017120"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.10.751"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.71041643.x"},{"key":"e_1_2_5_17_1","first-page":"188","volume-title":"Linkage disequilibrium between alleles at marker loci. Handbook of human genetic linkage","author":"Terwilliger J","year":"1994"},{"key":"e_1_2_5_18_1","first-page":"1107","article-title":"Testing linkage disequilibrium between a disease gene and marker loci","volume":"53","author":"Xie X","year":"1993","journal-title":"Am J Hum Genet"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.10798","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.10798","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T21:57:48Z","timestamp":1696975068000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.10798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11,27]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1002\/ajmg.b.10798"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.10798","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11,27]]}}}