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We investigated the possible role of <jats:italic>CLOCK<\/jats:italic> gene polymorphism in the regulation of diurnal mood fluctuations during a major depressive episode. Sample (n\u2009=\u2009101) was collected, in the context of previously reported trials, among patients affected by bipolar disorder type I, depressive episode without psychotic features, free of psychotropic medications. Perceived mood levels were assessed three times a day with self\u2010administered visual analogue scales. Genotype groups showed no significant difference in diurnal mood fluctuations. When stratifying the sample by including only patients with an adequate period of observation (duration of illness higher than 5 years, n\u2009=\u200969), we post\u2010hoc observed a significantly higher recurrence rate in homozygotes for the C variant, which was almost double than that of the other genotype groups. This preliminary observation leads to hypothesize a role for the <jats:italic>CLOCK<\/jats:italic> gene polymorphism in the regulation of long\u2010term illness recurrence in bipolar disorder. Given the post\u2010hoc nature of the finding, replication in independent samples is necessary to confirm it. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.20038","type":"journal-article","created":{"date-parts":[[2003,10,23]],"date-time":"2003-10-23T13:19:40Z","timestamp":1066915180000},"page":"23-26","source":"Crossref","is-referenced-by-count":283,"title":["Influence of <i>CLOCK<\/i> gene polymorphism on circadian mood fluctuation and illness recurrence in bipolar 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