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The study searched for risk loci for affective disorder by searching for homozygous segments or more complex inherited loci using parametric and non\u2010parametric multipoint linkage analysis. In addition dominant, multipoint, affecteds\u2010only linkage analyses were performed as a supplement to previous analyses. On chromosomes 2q31.3, 10, 12q24, and 21q22.3 evidence for a risk locus was obtained by parametric and\/or non\u2010parametric linkage analyses and by haplotype sharing. As other studies have found significant or suggestive linkage to bipolar disorder in these chromosome regions this suggests that an oligogenic mode of inheritance is possible in this family involving at least some of the loci. Finally, the work discusses whether homozygosity mapping using parametric and non\u2010parametric linkage analyses may be of value for complex diseases including rare subphenotypes of such disorders. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.20039","type":"journal-article","created":{"date-parts":[[2003,6,16]],"date-time":"2003-06-16T10:12:07Z","timestamp":1055758327000},"page":"63-71","source":"Crossref","is-referenced-by-count":28,"title":["Genome wide scan using homozygosity mapping and linkage analyses of a single pedigree with affective disorder suggests oligogenic inheritance"],"prefix":"10.1002","volume":"120B","author":[{"given":"Henrik","family":"Ewald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben A.","family":"Kruse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Mors","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,6,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/302185"},{"key":"e_1_2_6_3_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg910"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1404"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.25.2933"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.164.3.355"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000882"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970531)74:3<254::AID-AJMG4>3.0.CO;2-Q"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041444-199421000-00003"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041444-199800830-00002"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001074"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(20000207)96:1<18::AID-AJMG6>3.0.CO;2-G"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/302697"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0694supp-246"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000989"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.585"},{"key":"e_1_2_6_18_1","first-page":"519","article-title":"Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping","volume":"56","author":"Kruglyak L","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2884728"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/319507"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000915"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.23.13060"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191519098"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9297(07)62966-8"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19991015)88:5<567::AID-AJMG24>3.0.CO;2-8"},{"key":"e_1_2_6_26_1","volume-title":"Statistics in human genetics","author":"Sham P","year":"1998"},{"key":"e_1_2_6_27_1","first-page":"378","volume-title":"Human molecular genetics 2","author":"Strachan T","year":"1999"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1194-291"},{"key":"e_1_2_6_29_1","volume-title":"Handbook of human genetic linkage","author":"Terwilliger JD","year":"1994"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1086\/514855"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1086\/322996"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810180089012"},{"key":"e_1_2_6_33_1","volume-title":"The ICD\u201010 classification of mental and behavioural disorders. 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