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We detected a significantly higher recurrence of initial (<jats:italic>P<\/jats:italic>\u2009=\u20090.0001), middle (<jats:italic>P<\/jats:italic>\u2009=\u20090.0009), and early (<jats:italic>P<\/jats:italic>\u2009=\u20090.0008) insomnia in homozygotes for the C variant and a similar trend concerning decreased need of sleep in BP (<jats:italic>P<\/jats:italic>\u2009=\u20090.0074). Other demographic and clinical features were found not related with CLOCK polymorphisms. This preliminary observation leads to hypothesize a possible involvement of the <jats:italic>CLOCK<\/jats:italic> gene polymorphism in the sleep disregulations in MDD and BP. Copyright \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.20053","type":"journal-article","created":{"date-parts":[[2003,7,30]],"date-time":"2003-07-30T14:15:03Z","timestamp":1059574503000},"page":"35-38","source":"Crossref","is-referenced-by-count":215,"title":["Genetic dissection of psychopathological symptoms: Insomnia in mood disorders and <i>CLOCK<\/i> gene 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