{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:26:59Z","timestamp":1779114419036,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,8,29]],"date-time":"2003-08-29T00:00:00Z","timestamp":1062115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2004,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Susceptibility to Alzheimer's disease (AD) is thought to be regulated by multiple genetic factors. Recently, three independent studies have reported that loci on chromosome 10q are linked with AD, and the insulin degrading enzyme (IDE; MIM 146680) gene located on chromosome 10q23\u2010q25; <jats:italic>IDE<\/jats:italic> is located close to the maker D10S583, which exhibits a maximum LOD score for late\u2010onset AD. We examined seven polymorphisms in the <jats:italic>IDE<\/jats:italic> gene, the marker D10S583 in the 5\u2032 flanking region, and SNPs in introns 1, 3, 11, 20, 21, and 22 (rs#1999764, 1855915, 1970244, 538469, 551266, and 489517, respectively). Four SNPs in introns 3, 11, 20, and 22 did not exhibit any polymorphisms in the Japanese population that was studied. D10S583 and two SNPs in introns 1 and 21 did not exhibit a significant association with early\u2010 or late\u2010onset AD. In addition, no associations were observed for subgroups of AD grouped according to <jats:italic>APOE<\/jats:italic> status. The present study indicates that the <jats:italic>IDE<\/jats:italic> gene polymorphisms do not confer susceptibility to early\u2010 or late\u2010onset AD at least in a Japanese population. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.20106","type":"journal-article","created":{"date-parts":[[2004,1,28]],"date-time":"2004-01-28T09:00:26Z","timestamp":1075280426000},"page":"87-91","source":"Crossref","is-referenced-by-count":22,"title":["No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese 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