{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:10:07Z","timestamp":1787839807975,"version":"build-2784847793"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,9,29]],"date-time":"2003-09-29T00:00:00Z","timestamp":1064793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The low density lipoprotein receptor\u2010related protein 1 (<jats:italic>LRP1<\/jats:italic> gene) is a candidate gene for Alzheimer's disease (AD), because it is a ligand for proteins involved in AD pathogenesis, such as apolipoprotein E (APOE), \u03b12\u2010macroglobulin (A2M), amyloid precursor protein (APP), and is located on chromosome 12, within a region linked with AD. An association between a silent polymorphism (C\/T) in exon 3 and late onset AD has been reported, with an increased frequency of the C allele, although with conflicting results. We examined this polymorphism in a cohort of 166 sporadic AD patients and 225 sex\u2010 and age\u2010matched nondemented controls from Southern Italy. No statistically significant differences were found in LRP1 genotype and allele frequencies between the whole AD sample and controls, nor in early\u2010 and late\u2010onset subsets of AD patients. No statistically significant differences in frequencies between LRP1 alleles and AD among APOE allele, age, or gender strata were found. Finally, comparing our results with the findings from other European populations, the LRP1 C allele frequency showed a statistically significant decreasing trend from Northern to Southern regions of Europe, with a concomitant increase in LRP1 T allele frequency, but in AD patients only. Finally, in the AD sample, a decreasing geographical trend from North to South of Europe was found for LRP1 CC genotype, and an inverse trend for LRP1 CT genotype frequency. We suggest that these regional variations in LRP1 genotype and allele frequencies in AD could be related to the different patterns of association between this polymorphism and the disease in various European studies. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.20146","type":"journal-article","created":{"date-parts":[[2004,3,23]],"date-time":"2004-03-23T13:33:17Z","timestamp":1080048797000},"page":"69-73","source":"Crossref","is-referenced-by-count":20,"title":["Regional European differences in allele and genotype frequencies of low density lipoprotein receptor\u2010related protein 1 polymorphism in Alzheimer's disease"],"prefix":"10.1002","volume":"126B","author":[{"given":"Francesco","family":"Panza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"D'Introno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Colacicco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Capurso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Basile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Capurso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Capurso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Solfrizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,9,29]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00294-8"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00888-X"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(00)01304-5"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2000.580410.x"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.6.1905"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(00)00443-3"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00141-4"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.49.1.56"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)78749-3"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1474"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00860-5"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.8.1159"},{"key":"e_1_2_3_15_1","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1001\/jama.1997.03550150041033","article-title":"Complete genomic screen in late\u2010onset familial Alzheimer disease: Evidence for a new locus on chromosome 12","volume":"278","author":"Pericak\u2010Vance MA","year":"1997","journal-title":"JAMA"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1371"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)02342-4"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.72.6.732"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)77848-X"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.20146","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.20146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T14:18:25Z","timestamp":1697638705000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.20146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9,29]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["10.1002\/ajmg.b.20146"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.20146","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9,29]]}}}