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Based on previous work with the catechol\u2010<jats:italic>O<\/jats:italic>\u2010methyltransferase (COMT) 158 polymorphism, we hypothesized that the Met\u2013Met homozygotes would be more hostile than the heterozygotes and the Val\u2013Val homozygotes. Hostility ratings at baseline were used to test this hypothesis. The Met\u2013Met homozygotes (N\u2009=\u20097) were found to have significantly higher levels of hostility than the other patients (N\u2009=\u200953). The hypothesis was thus supported. The finding should be replicated in a larger sample. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.20149","type":"journal-article","created":{"date-parts":[[2004,4,20]],"date-time":"2004-04-20T17:10:48Z","timestamp":1082481048000},"page":"28-29","source":"Crossref","is-referenced-by-count":24,"title":["COMT158 polymorphism and hostility"],"prefix":"10.1002","volume":"127B","author":[{"given":"Jan","family":"Volavka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.","family":"Kennedy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingqun","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pal","family":"Czobor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Nolan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Sheitman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Pierre","family":"Lindenmayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Citrome","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"McEvoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Lieberman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,9,19]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01416-6"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.52.11.1510"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.179.4.351"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(88)90038-8"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19991215)88:6<628::AID-AJMG10>3.0.CO;2-E"},{"key":"e_1_2_3_7_1","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1176\/ajp.155.6.835","article-title":"Association between catechol O\u2010methyltransferase genotype and violence in schizophrenia and schizoaffective disorder","volume":"155","author":"Lachman HM","year":"1998","journal-title":"Am J Psychiatry"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00098-0"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(96)03111-3"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.2.255"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.20149","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.20149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T01:05:27Z","timestamp":1734311127000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.20149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9,19]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,5,15]]}},"alternative-id":["10.1002\/ajmg.b.20149"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.20149","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9,19]]}}}