{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:13:55Z","timestamp":1789449235912,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,9,24]],"date-time":"2003-09-24T00:00:00Z","timestamp":1064361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2004,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several lines of evidence suggest that genetic factors might contribute to the pathogenesis of eating disorders and that brain\u2010derived neurotrophic factor (BDNF) plays a role in the pathophysiology of eating disorders. To investigate the role of the <jats:italic>BDNF<\/jats:italic> gene in the susceptibility to eating disorders, we analyzed the BDNF 196G\/A gene polymorphism in female patients with eating disorders and female normal controls. The difference in the genotype frequency between patients (n\u2009=\u2009198) and normal controls (n\u2009=\u2009222) was statistically significant (<jats:italic>P<\/jats:italic>\u2009=\u20090.029). Interestingly, a significant (<jats:italic>P<\/jats:italic>\u2009=\u20090.015) difference in the genotype frequency between normal controls and bulimia nervosa patients (n\u2009=\u2009101) with binge\u2010purging type was detected. This study suggests that the BDNF 196G\/A gene polymorphism might be associated with a susceptibility to eating disorders.\u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.20153","type":"journal-article","created":{"date-parts":[[2004,4,20]],"date-time":"2004-04-20T17:15:38Z","timestamp":1082481338000},"page":"125-127","source":"Crossref","is-referenced-by-count":59,"title":["Association between the brain\u2010derived neurotrophic factor 196G\/A polymorphism and eating disorders"],"prefix":"10.1002","volume":"127B","author":[{"given":"Hiroki","family":"Koizumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Nakazato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Ohgake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Koike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoe","family":"Okamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachio","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Murayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaomi","family":"Iyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,9,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904083401407"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00195-8"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00035-7"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12378-1"},{"key":"e_1_2_5_6_1","article-title":"Association between brain\u2010derived neurotrophic factor 196G\/A polymorphism and personality traits in healthy subjects","author":"Itoh K","year":"2003","journal-title":"Am J Med Genet"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.51.1.299"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.58.11.1005"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.6.1290"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.26.15239"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008104200"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)01292-2"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01746-8"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00653-0"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/342288"},{"key":"e_1_2_5_16_1","article-title":"Ethnic difference of the BDNF 196G\/A (val66met) polymorphism frequencies: The possibility to explain ethnic mental traits","author":"Shimizu E","year":"2003","journal-title":"Am J. 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