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Prompted by the notion that angiotensin may be involved in the control of respiration, heart rate variability, and anxiety\u2010like behavior, we investigated the putative association between polymorphisms in three angiotensin\u2010related genes and panic disorder\u2014angiotensinogen (<jats:italic>AGT<\/jats:italic>), angiotensin converting enzyme (<jats:italic>ACE<\/jats:italic>), and angiotensin II (ANG II) receptor type 1 (<jats:italic>ATr1<\/jats:italic>) in 72 patients with panic disorder and 504 controls. Allele and genotype distribution of the ATr1 A1166C allele and the AGT M235T did not differ between patients and controls. With respect to the ACE I\/D polymorphism, the I allele was found to be more frequent in male (\u03c7<jats:sup>2<\/jats:sup>\u2009=\u20098.042, df\u2009=\u20091, <jats:italic>P<\/jats:italic>\u2009=\u20090.005), but not female, panic disorder patients than in controls. The results of this investigation provide preliminary evidence for the suggestion that angiotensin\u2010related genes may be associated with panic disorder in men. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.20164","type":"journal-article","created":{"date-parts":[[2004,4,20]],"date-time":"2004-04-20T17:13:34Z","timestamp":1082481214000},"page":"81-84","source":"Crossref","is-referenced-by-count":42,"title":["Angiotensin\u2010related genes in patients with panic disorder"],"prefix":"10.1002","volume":"127B","author":[{"given":"Marie","family":"Olsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Annerbrink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Westberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Melke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fariba","family":"Baghaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Rosmond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"Holm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Andersch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christer","family":"Allgulander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1995.tb44679.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.24.1.63"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)01019-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00004-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)01089-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00823-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.141.7.857"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800250035006"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(89)90343-0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.10.1568"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.278.5.R1125"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90275-H"},{"key":"e_1_2_6_14_1","unstructured":"KeimSR SajdykTJ ShekharA.2001.Panic\u2010like responses elicited by lactate infusions in amygdala primed rats is mediated via angiotensin\u2010II. 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