{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T19:44:46Z","timestamp":1788291886034,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,3,22]],"date-time":"2004-03-22T00:00:00Z","timestamp":1079913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Accumulating evidence indicates that the heparan\u2010sulfate\u2010proteoglycan (perlecan, HSPG2), as well as other specific proteoglycans, are involved in amyloidogenesis and tau aggregation in Alzheimer's disease (AD). Moreover, the HSPG2 is located on chromosome 1p36, a region of linkage to late\u2010onset AD (LOAD). These two criteria, pathological and positional, make the HSPG2 an interesting candidate for an association with AD. We performed a case\u2010control association study between the common intron 6 BamHI polymorphism at a region of putative heparan\u2010sulfate (HS) attachment sites in the <jats:italic>HSPG2<\/jats:italic> gene and sporadic AD in Jews. No association was detected with AD, neither as a risk factor nor as a modifier gene affecting the age at disease onset and disease progression. In addition, no interactive effect was found with the known risk factor for AD, the apolipoprotein E (APOE) \u03b54. These findings show no evidence for association between HSPG2 intron 6 BamHI polymorphism and AD in our population. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30015","type":"journal-article","created":{"date-parts":[[2004,4,15]],"date-time":"2004-04-15T15:08:41Z","timestamp":1082041721000},"page":"123-125","source":"Crossref","is-referenced-by-count":11,"title":["An association study of a polymorphism in the heparan sulfate proteoglycan gene (perlecan, <i>HSPG2<\/i>) and Alzheimer's 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