{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:32:51Z","timestamp":1764995571857},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,5,24]],"date-time":"2004-05-24T00:00:00Z","timestamp":1085356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2004,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Changes in the function of the serotonergic system influence both panic phobic symptoms and carbon dioxide (CO<jats:sub>2<\/jats:sub>) reactivity in patients with panic disorder. Schmidt et al. [2000: J Abnorm Psychol 109(2):308\u2013320] recently reported a predictive role of the genetic variants of the 5\u2010HTTLPR on the fearful response to CO<jats:sub>2<\/jats:sub> in healthy controls. We tested the hypothesis that the heterogeneity of CO<jats:sub>2<\/jats:sub> reactivity in patients with panic disorder could be related to the allelic variation of the 5\u2010HTT promoter. Ninety\u2010five patients with panic disorder were challenged with 35% CO<jats:sub>2<\/jats:sub>. 5\u2010HTTLPR allelic variation in each subject was determined using a PCR\u2010based method. There were no differences for all the measures of CO<jats:sub>2<\/jats:sub> reactivity among the genotype groups. CO<jats:sub>2<\/jats:sub> reactivity of patients with panic disorder seems not to be influenced by the genetic variants of the 5\u2010HTTLPR; this finding does not support a role for the serotonin transporter in the etiopathogenesis of CO<jats:sub>2<\/jats:sub> reactivity in panic disorder. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30035","type":"journal-article","created":{"date-parts":[[2004,5,24]],"date-time":"2004-05-24T21:00:52Z","timestamp":1085432452000},"page":"41-43","source":"Crossref","is-referenced-by-count":18,"title":["Lack of relationship between CO<sub>2<\/sub> reactivity and serotonin transporter gene regulatory region polymorphism in panic disorder"],"prefix":"10.1002","volume":"129B","author":[{"given":"Giampaolo","family":"Perna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela 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