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We searched for the role of <jats:italic>BDNF<\/jats:italic> variants in obesity, eating disorders, and attention\u2010deficit\/hyperactivity disorder (ADHD). A mutation screen (SSCP and DHPLC) of the translated region of <jats:italic>BDNF<\/jats:italic> in 183 extremely obese children and adolescents and 187 underweight students was performed. Additionally, we genotyped two common polymorphisms (rs6265: p.V66M; c.\u221246C\u2009&gt;\u2009T) in 118 patients with anorexia nervosa, 80 patients with bulimia nervosa, 88 patients with ADHD, and 96 normal weight controls. Three rare variants (c.5C\u2009&gt;\u2009T: p.T2I; c.273G\u2009&gt;\u2009A; c.*137A\u2009&gt;\u2009G) and the known polymorphism (p.V66M) were identified. A role of the I2 allele in the etiology of obesity cannot be excluded. We found no association between p.V66M or the additionally genotyped variant c.\u221246C\u2009&gt;\u2009T and obesity, ADHD or eating disorders. This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.interscience.wiley.com\/jpages\/0148-7299:1\/suppmat\/index.html\">http:\/\/www.interscience.wiley.com\/jpages\/0148\u20107299:1\/suppmat\/index.html<\/jats:ext-link>. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30090","type":"journal-article","created":{"date-parts":[[2004,9,29]],"date-time":"2004-09-29T16:06:22Z","timestamp":1096473982000},"page":"96-99","source":"Crossref","is-referenced-by-count":126,"title":["Mutation screen of the brain derived neurotrophic factor gene (<i>BDNF<\/i>): Identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention\u2010deficit\/hyperactivity 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