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In the present study, homozygosity mapping was applied to 24 persons with bipolar disorder from 22 inbred families. The families were selected irrespective of whether other affected family members were present or not. A genome wide screen using genotypes from only a single affected person in each family was performed using the AFFYMETRIX GeneChip HuSNP Mapping Assay, which contains 1,494 single nucleotide polymorphisms. At chromosome 17q24\u2010q25 a parametric multipoint LOD score of 1.96 was found at WIAF\u20102407 and WIAF\u20102405. When analyzing 19 additional microsatellite markers on chromosome 17q the maximum parametric multipoint LOD score was 2.08, 1.5 cM proximal to D17S668. The present study replicates a recent significant linkage finding. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30106","type":"journal-article","created":{"date-parts":[[2004,11,24]],"date-time":"2004-11-24T01:17:56Z","timestamp":1101259076000},"page":"25-30","source":"Crossref","is-referenced-by-count":18,"title":["A genome\u2010wide search for risk genes using homozygosity mapping and microarrays with 1,494 single\u2010nucleotide polymorphisms in 22 eastern Cuban families with bipolar 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