{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:10:26Z","timestamp":1778577026527,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,23]],"date-time":"2005-02-23T00:00:00Z","timestamp":1109116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2005,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We performed an affected sib\u2010pair (ASP) linkage analysis to test for the effects of age at onset (AAO), rate of decline (ROD), and Apolipoprotein E (APOE) genotype on linkage to late\u2010onset Alzheimer's disease (AD) in a sample comprising 428 sib\u2010pairs. We observed linkage of mean AAO to chromosome 21 in the whole sample (max LOD\u2009=\u20092.57). This came entirely from the NIMH sample (max LOD\u2009=\u20093.62), and was strongest in pairs with high mean AAO (&gt;80). A similar effect was observed on chromosome 2q in the NIMH sample (max LOD\u2009=\u20092.73); this region was not typed in the IADC\/UK sample. Suggestive evidence was observed in the combined sample of linkage of AAO difference to chromosome 19q (max LOD\u2009=\u20092.33) in the vicinity of APOE and 12p (max LOD\u2009=\u20092.22), with linkage strongest in sib\u2010pairs with similar AAO. Mean ROD showed suggestive evidence of linkage to chromosome 9q in the whole sample (max LOD\u2009=\u20092.29), with the effect strongest in the NIMH sample (max LOD\u2009=\u20093.58), and in pairs with high mean ROD. Additional suggestive evidence was also observed in the NIMH sample with AAO difference on chromosome 6p (max LOD\u2009=\u20092.44) and 15p (max LOD\u2009=\u20091.87), with linkage strongest in pairs with similar AAO, and in the UK sample with mean ROD on chromosome 1p (max LOD\u2009=\u20092.73, linkage strongest in pairs with high mean ROD). We also observed suggestive evidence of increased identical by descent (IBD) in APOE \u03b54 homozygotes on chromosome 1 (max LOD\u2009=\u20093.08) and chromosome 9 (max LOD\u2009=\u20093.34). The previously reported genome\u2010wide linkage of AD to chromosome 10 was not influenced by any of the covariates studied. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30114","type":"journal-article","created":{"date-parts":[[2005,2,23]],"date-time":"2005-02-23T17:48:49Z","timestamp":1109180929000},"page":"24-32","source":"Crossref","is-referenced-by-count":54,"title":["Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's 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