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A binomal test is used to evaluate whether linked regions overlap more than expected by chance for 15 genome\u2010wide scans in autism, ADHD, and dyslexia. Significant evidence of linkage overlap (<jats:italic>P<\/jats:italic>\u2009=\u200910<jats:sup>\u22127<\/jats:sup>) is seen for autism, ADHD, and dyslexia for seven chromosomal regions (2p11\u201312, 5p13, 7q22\u201333, 9q33\u201334, 13q22, 16p13, and 17p11\u2013q11). Linkage analysis of ACA and molecular markers for 270 sibling pairs with ADHD is conducted using the Haseman\u2013Elston statistic. Linkage analysis supports ACA as a shared phenotype with risk genes located on 9q33\u201334 or 16p13 (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.004). Further support stems from the overlap of these regions in schizophrenia, bipolar illness, specific language impairment (SLI), and handedness, all traits associated with ACA. Autism, ADHD, and dyslexia share regions of linkage overlap and ACA may be a shared phenotype for such genes similar to HLA in autoimmune disease. Because ACA is associated with certain aspects of creativity, such risk genes may also be enhancer genes for creativity. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30141","type":"journal-article","created":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T17:51:04Z","timestamp":1112377864000},"page":"79-84","source":"Crossref","is-referenced-by-count":51,"title":["Toward localizing genes underlying cerebral asymmetry and mental health"],"prefix":"10.1002","volume":"135B","author":[{"given":"Susan L.","family":"Smalley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra K.","family":"Loo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May H.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita M.","family":"Cantor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.GIM.0000110413.07490.0B"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/338241"},{"key":"e_1_2_7_4_1","volume-title":"DSM IV: Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-440X(88)90044-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1006\/brcg.1999.1080"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/342720"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/375143"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19991215)88:6<609::AID-AJMG7>3.0.CO;2-L"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2001.030302.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/brln.2000.2308"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02916254"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/320588"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.20002"},{"key":"e_1_2_7_15_1","first-page":"664","article-title":"A new gene (DYX3) for dyslexia is located on chromosome 2","volume":"36","author":"Fagerheim T","year":"1999","journal-title":"J Med Genet"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.7.1052"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn936"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng792"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/340112"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617702811031"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20010715)101:4<370::AID-AJMG1223>3.0.CO;2-G"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052494999"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2001.tb05772.x"},{"key":"e_1_2_7_24_1","unstructured":"HaleTS.2004.Brain laterality in adults with attention\u2010deficit\/hyperactivity disorder. 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