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In a sample of 252 healthy subjects, a significant association between variations observed in nicotine dependence and the heterozygous AC\u2010genotype of the TPH A779C polymorphism could be demonstrated. Moreover, the heterozygous genotype was significantly associated with a personality trait of neurotic aggression (indirect hostility, negativism), as measured by the Buss\u2013Durkee\u2010Hostility\u2010Inventory (BDHI). The positive heterosis effects with respect to nicotine addiction and personality support the idea that the <jats:italic>TPH1<\/jats:italic> gene exerts pleiotropic effects. \u00a9 2004 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30153","type":"journal-article","created":{"date-parts":[[2005,1,5]],"date-time":"2005-01-05T14:48:23Z","timestamp":1104936503000},"page":"20-24","source":"Crossref","is-referenced-by-count":35,"title":["Pleiotropic effect of the TPH A779C polymorphism on nicotine dependence and 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