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We have performed association analyses using the polymorphism to determine the PBR in PD. We screened the subjects for sequence variations within the 5\u2032 region, the coding region (exons 2\u20134), and the 3\u2032 noncoding region. One novel missense variant in exon 4, derived from the nucleotide transition in codon 162 (CGT\u2009\u2192\u2009CAT:485G\u2009&gt;\u2009A) resulting in an arginine\u2010to\u2010histidine (Arg\u2009\u2192\u2009His) change, was detected in these subjects. The 485G\u2009&gt;\u2009polymorphism of the <jats:italic>PBR<\/jats:italic> gene was analyzed in 91 PD patients and 178 controls. The genotypic and allelic analyses of the 485G\u2009&gt;\u2009A revealed significant differences between the panic patients and the comparison subjects (<jats:italic>P<\/jats:italic>\u2009=\u20090.021 and 0.014, respectively). The present study provides new and important evidence that variation in the <jats:italic>PBR<\/jats:italic> gene influences susceptibility to PD. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30211","type":"journal-article","created":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T18:18:31Z","timestamp":1141237111000},"page":"222-226","source":"Crossref","is-referenced-by-count":38,"title":["Evidence that variation in the peripheral benzodiazepine receptor <i>(PBR)<\/i> gene influences susceptibility to panic 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