{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:46:55Z","timestamp":1791190015635,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,8,4]],"date-time":"2005-08-04T00:00:00Z","timestamp":1123113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2005,11,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Probands with late onset Alzheimer's disease (LOAD) exhibit positive symptoms of psychosis, 30\u201360% of the time. Positive symptoms of psychosis have been shown to appear prior to the onset of dementia to be accompanied by greater cognitive deficits, and to predict a more rapid decline. A study of the distribution of AD with psychosis (ADP) in families from the NIMH Alzheimer's Disease Genetic Initiative sample indicates that the trait is heritable, and linkage studies of multiplex ADP families have found suggestive peaks on 2p, 6q, 8p, and 21q. A genome scan of idiopathic psychosis, schizophrenia, in the Icelandic population identified a risk haplotype within the 5\u2032 region of neuregulin\u20101 (<jats:italic>NRG1<\/jats:italic>) on 8p12. Associations with <jats:italic>NRG<\/jats:italic>1 SNPs have also been found in other schizophrenia populations from Scotland, Ireland, and China. Here, we report results demonstrating a significant linkage peak for ADP on 8p12 in the NIMH AD dataset, encompassing the NRG1 region. We also demonstrate that there is a significant association with a NRG1 SNP (single nucleotide polymorphism), rs392499, with ADP, \u03c7<jats:sup>2<\/jats:sup>\u2009=\u20097.0, <jats:italic>P<\/jats:italic>\u2009=\u20090.008. This same SNP is part of a 3\u2010SNP haplotype preferentially transmitted to individuals with this phenotype. Our results suggest that NRG1 plays a role in increasing the genetic risk to positive symptoms of psychosis in a proportion of LOAD families. \u00a9 2005 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30219","type":"journal-article","created":{"date-parts":[[2005,8,4]],"date-time":"2005-08-04T20:16:32Z","timestamp":1123186592000},"page":"28-32","source":"Crossref","is-referenced-by-count":54,"title":["Neuregulin\u20101 polymorphism in late onset Alzheimer's disease families with psychoses"],"prefix":"10.1002","volume":"139B","author":[{"given":"Rodney C. P.","family":"Go","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney T.","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Wiener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan S.","family":"Bassett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Blacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernie","family":"Devlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Sweet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,8,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.1.118"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-200507000-00011"},{"issue":"12","key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"6496","DOI":"10.1128\/MCB.15.12.6496","article-title":"Neu differentiation factor activation of ErbB\u20103 and ErbB\u20104 is cell specific and displays a differential requirement for ErbB\u20102","volume":"15","author":"Beerli RR","year":"1995","journal-title":"Mol Cell Biol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.1.139"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg007"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90564-9"},{"issue":"19","key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"14303","DOI":"10.1016\/S0021-9258(17)36789-3","article-title":"The erbB3 gene product is a receptor for heregulin","volume":"269","author":"Carraway KL","year":"1994","journal-title":"J Biol Chem"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/62.1.42"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001412"},{"key":"e_1_2_6_11_1","volume-title":"Sib\u2010pair linkage program (SIBPAL)","author":"Elston R","year":"1997"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4827(02)00102-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.12.1165"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.256.5060.1205"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/302137"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200625"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001456"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/301592"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.10.4833"},{"issue":"6","key":"e_1_2_6_20_1","first-page":"1347","article-title":"Parametric and nonparametric linkage analysis: A unified multipoint approach","volume":"58","author":"Kruglyak L","year":"1996","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.12.131"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110371200"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001485"},{"issue":"1","key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1176\/jnp.13.1.50","article-title":"The psychotic phenomenon in probable Alzheimer's disease: A positron emission tomography study","volume":"13","author":"Lopez OL","year":"2001","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(04)80107-6"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-08-03164.2003"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.1.53"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.2466\/pr0.1962.10.3.799"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.10.1965"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950151207"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001608"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/366473a0"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1086\/342734"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1086\/345442"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2004.07.029"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.7.4.476"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610200006657"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.6.907"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00009-X"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001262"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001550"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.12.1955"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001348"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.146.5.577"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001377"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.30219","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.30219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T02:05:49Z","timestamp":1693706749000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.30219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,4]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,11,5]]}},"alternative-id":["10.1002\/ajmg.b.30219"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.30219","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,4]]}}}