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The disease progresses slowly with loss of fine motor skills, ataxia, and affected individuals may survive for two decades after onset of symptoms. The molecular basis behind ADLD remains unknown but the causative locus was previously mapped to a 4 cM region on chromosome 5. We have recently identified a large family of Swedish origin with this type of ADLD. Linkage analysis on samples from family members confirmed linkage to 5q23 and supports genetic homogeneity for the disease. We fine mapped and localized the <jats:italic>ADLD<\/jats:italic> gene to a 0.96 cM region between <jats:italic>D5S1495<\/jats:italic> and <jats:italic>CTT\/CCT15<\/jats:italic>. A maximum parametric multipoint location score of 9.45 was obtained for a position at the marker <jats:italic>CTT55<\/jats:italic>. From our results we conclude that the <jats:italic>ADLD<\/jats:italic> gene locus is restricted to a 1.47 Mbp interval containing 13 known or putative genes. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30342","type":"journal-article","created":{"date-parts":[[2006,7,6]],"date-time":"2006-07-06T05:44:07Z","timestamp":1152164647000},"page":"608-614","source":"Crossref","is-referenced-by-count":24,"title":["Adult\u2010onset autosomal dominant leukodystrophy with autonomic symptoms restricted to 1.5 Mbp on chromosome 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