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The cause of both the sporadic and inherited forms of MD remains unclear despite a number of candidate genes defined from their association with hearing loss. We have performed a genome wide linkage scan on a large Swedish family segregating MD in five generations. Five candidate regions with a lod score of &gt;1 were identified. Two additional families with autosomal dominant MD were analyzed for linkage to these regions and a cumulative Z<jats:sub>max<\/jats:sub> of 3.46 was obtained for a single region on chromosome 12p. In two of the three families, a shared haplotype was found to extend over 1.7 Mb which suggests a common ancestral origin. Within this region, a single recombination event restricts the candidate region to 463 kb. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30347","type":"journal-article","created":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T20:11:56Z","timestamp":1149192716000},"page":"463-467","source":"Crossref","is-referenced-by-count":48,"title":["A Meniere's disease gene linked to chromosome 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