{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:53:53Z","timestamp":1790009633403,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2006,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The chromosome 10q region has recently received a great deal of attention in late\u2010onset Alzheimer's disease (LOAD), given the growing evidence of linkage to LOAD, or to A\u2010beta levels, reported by several groups. In a recent paper we reported evidence of linkage in this region in our subset of the NIMH AD genetics initiative pedigrees, approaching genome\u2010wide significance (non\u2010parametric LOD score\u2009=\u20093.27), when only families with maternal disease origin were analyzed [Bassett et al. (2002); Am J Med Genet 114:679\u2013686]. We have now extended this work, using an independent subset of NIMH AD pedigrees from the University of Alabama at Birmingham (UAB), and show further evidence of linkage using parent\u2010of\u2010origin information. As in our Hopkins sample, maternal but not paternal pedigrees show significantly increased linkage in the chromosome 10q region compared to the unstratified sample. Combining data from our previous fine\u2010mapping work on this region and five new markers genotyped in all pedigrees results in a non\u2010parametric LOD score of 3.73 in the same region, a value that reaches genome wide significance for linkage, with an empirical <jats:italic>P<\/jats:italic> value\u2009=\u20090.003. These results support our earlier findings and narrow the region of interest. In combination with findings from other groups, these results provide further evidence that this chromosome 10 region harbors a gene implicated in LOAD, and our use of parent\u2010of\u2010origin information has been useful in further narrowing the region of interest. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30350","type":"journal-article","created":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T20:06:22Z","timestamp":1149192382000},"page":"537-540","source":"Crossref","is-referenced-by-count":24,"title":["Further evidence of a maternal parent\u2010of\u2010origin effect on chromosome 10 in late\u2010onset Alzheimer's disease"],"prefix":"10.1002","volume":"141B","author":[{"given":"Susan Spear","family":"Bassett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Avramopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney T.","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Wiener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Bracie","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney C. P.","family":"Go","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Daniele","family":"Fallin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,6]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng786"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10648"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2003.11.018"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2728(98)00165-0"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02438.x"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004390100463"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.1.254"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5500.2303"},{"key":"e_1_2_3_10_1","unstructured":"HindsD RischN.1996.The ASPEX package: Affected sib\u2010pair mapping.ftp:\/\/lahmed.stanford.edu\/pub\/aspex."},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02991575"},{"key":"e_1_2_3_12_1","first-page":"730","article-title":"Non\u2010Mendelian transmission in dentatorubral\u2010pallidoluysian atrophy and Machado\u2010Joseph disease: The mutant allele is preferentially transmitted in male meiosis","volume":"58","author":"Ikeuchi T","year":"1996","journal-title":"Am J Hum Genet"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970150909"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8817.2004.00110.x"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.2.237"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0009-9163.2004.00236.x"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(97)80023-2"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-828439"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/301592"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.18.2767"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313080200"},{"key":"e_1_2_3_22_1","first-page":"343","article-title":"Sex\u2010dependent mechanisms for expansions and contractions of the CAG repeat on affected Huntington disease chromosomes","volume":"57","author":"Kremer B","year":"1995","journal-title":"Am J Hum Genet"},{"key":"e_1_2_3_23_1","first-page":"1347","article-title":"Parametric and nonparametric linkage analysis: A unified multipoint approach","volume":"58","author":"Kruglyak L","year":"1996","journal-title":"Am J Hum Genet"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2006.03221.x"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01912-3"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1091230"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10183"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1425"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000022023"},{"key":"e_1_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-004-0156-5"},{"key":"e_1_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(02)53013-0"},{"key":"e_1_2_3_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.04.051"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.30350","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.30350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T20:14:48Z","timestamp":1696968888000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.30350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,7,5]]}},"alternative-id":["10.1002\/ajmg.b.30350"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.30350","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}