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The syndrome is associated with general cognitive impairments and specific deficits in visual\u2010spatial ability, non\u2010verbal reasoning, and planning skills. 22q11DS is also associated with behavioral and psychiatric abnormalities, including a markedly elevated risk for schizophrenia. Research findings indicate that people with schizophrenia, as well as those identified as schizoptypic, show specific cognitive deficits in the areas of sustained attention, executive functioning, and verbal working memory. The present study examined such schizophrenic\u2010like cognitive deficits in children and adolescents with 22q11DS (n\u2009=\u200926) and controls (n\u2009=\u200925) using a cross\u2010sectional design. As hypothesized, 22q11DS participants exhibited deficits in intelligence, achievement, sustained attention, executive functioning, and verbal working memory compared to controls. Furthermore, deficits in attention and executive functioning were more pronounced in the 22q11DS sample relative to general cognitive impairment. These findings suggest that the same pattern of neuropsychological impairment seen in patients with schizophrenia is present in non\u2010psychotic children identified as at\u2010risk for the development of schizophrenia based on a known genetic risk marker. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30379","type":"journal-article","created":{"date-parts":[[2006,10,10]],"date-time":"2006-10-10T18:23:57Z","timestamp":1160504637000},"page":"27-36","source":"Crossref","is-referenced-by-count":97,"title":["Schizophrenic\u2010like neurocognitive deficits in children and adolescents with 22q11 deletion syndrome"],"prefix":"10.1002","volume":"144B","author":[{"given":"Kathryn Eve","family":"Lewandowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vandana","family":"Shashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peggy M.","family":"Berry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Kwapil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,10]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"267","article-title":"An investigation of semantic space in patients with schizophrenia","volume":"2","author":"Aloia MS","year":"1996","journal-title":"J Clin Exp Neuropsychol"},{"key":"e_1_2_9_3_1","volume-title":"Diagnostic and statistical manual","author":"American Psychological Association","year":"2001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.56.9.781"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00152-3"},{"key":"e_1_2_9_6_1","unstructured":"Barrantes\u2010VidalN Caparr\u00f3sB ObiolsJE.1999.California Verbal Learning Test and schizotypal dimensions in normal adolescents. 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