{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:54:02Z","timestamp":1790880842012,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,8,18]],"date-time":"2006-08-18T00:00:00Z","timestamp":1155859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2006,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous investigations have suggested that ghrelin, an endogenous orexigenic peptide, is involved in the pathology of eating disorders. We conducted a study to determine whether any preproghrelin gene polymorphisms are associated with eating disorders. Three hundred thirty\u2010six eating disorder patients, including 131 anorexia nervosa (AN)\u2010restricting types (AN\u2010R), 97 AN\u2010binge eating\/purging types (AN\u2010BP) and 108 bulimia nervosa (BN)\u2010purging types (BN\u2010P), and 300 healthy control subjects participated in the study. Genotyping was performed to determine the polymorphisms present, and with this information, linkage disequilibrium (LD) between the markers was analyzed and the distributions of the genotypes, the allele frequencies, and the haplotype frequencies were compared between the groups. The Leu72Met (408 C\u2009&gt;\u2009A) (rs696217) polymorphism in exon 2 and the 3056 T\u2009&gt;\u2009C (rs2075356) polymorphism in intron 2 were in LD (D\u2032\u2009=\u20090.902, r<jats:sup>2<\/jats:sup>\u2009=\u20090.454). Both polymorphisms were significantly associated with BN\u2010P (allele\u2010wise: <jats:italic>P<\/jats:italic>\u2009=\u20090.0410, odds ratio (OR)\u2009=\u20091.48; <jats:italic>P<\/jats:italic>\u2009=\u20090.0035, OR\u2009=\u20091.63, for Leu72Met and 3056 T\u2009&gt;\u2009C, respectively). In addition, we observed a significant increase in the frequency of the haplotype Met72\u20103056C in BN\u2010P patients (<jats:italic>P<\/jats:italic>\u2009=\u20090.0059, OR\u2009=\u20091.71). Our findings suggest that the Leu72Met (408 C\u2009&gt;\u2009A) and the 3056 T\u2009&gt;\u2009C polymorphisms of the preproghrelin gene are associated with susceptibility to BN\u2010P. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30387","type":"journal-article","created":{"date-parts":[[2006,8,18]],"date-time":"2006-08-18T17:13:47Z","timestamp":1155921227000},"page":"929-934","source":"Crossref","is-referenced-by-count":52,"title":["Possible role of preproghrelin gene polymorphisms in susceptibility to bulimia 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