{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:53:07Z","timestamp":1762541587484},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T00:00:00Z","timestamp":1160956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2007,1,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has been hypothesized that insulin\u2010like growth factors (IGFs) and components of the growth\u2010hormone (GH)\u2010IGF axis may underlie reported associations of poor fetal and childhood growth with schizophrenia. We have investigated the association of schizophrenia with 16 SNPs spanning the <jats:italic>IGF1<\/jats:italic> gene with an inter\u2010marker distance of approximately 2\u20133 kb. We also examined associations with four common functional polymorphisms of genes involved in aspects of the GH\u2010IGF system\u2014the <jats:italic>IGF1 receptor (IGF1R), insulin receptor substrate (IRS1), growth hormone (GH1), and IGF binding protein\u20103 (IGFBP3).<\/jats:italic> The study was based on an analysis of pooled DNA samples from 648 UK and Irish cases of schizophrenia and 712 blood donor controls and of 297 Bulgarian parent offspring trios. In replicated pool analyses, none of the 16 SNPs in <jats:italic>IGF1<\/jats:italic> nor the 4 key SNPs in the other growth pathway genes were associated with schizophrenia. SNP coverage of <jats:italic>IGF1<\/jats:italic> was extensive, so our findings do not support a major role for <jats:italic>IGF\u2010I<\/jats:italic> in the aetiology of <jats:italic>schizophrenia<\/jats:italic>. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30396","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T11:45:32Z","timestamp":1161085532000},"page":"117-120","source":"Crossref","is-referenced-by-count":16,"title":["<i>IGF1<\/i>, growth pathway polymorphisms and schizophrenia: A pooling study"],"prefix":"10.1002","volume":"144B","author":[{"given":"D.","family":"Gunnell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Georgieva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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