{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T06:47:07Z","timestamp":1759042027006},"reference-count":34,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2006,8,18]],"date-time":"2006-08-18T00:00:00Z","timestamp":1155859200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2006,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A functional polymorphism (Val\u2010158\u2010Met) at the Catechol\u2010<jats:italic>O<\/jats:italic>\u2010methyltransferase (<jats:italic>COMT<\/jats:italic>) locus has been identified as a potential etiological factor in schizophrenia. Yet the association has not been convincingly replicated across independent samples. We hypothesized that phenotypic heterogeneity might be diluting the <jats:italic>COMT<\/jats:italic> effect. To clarify the putative association, we performed an exploratory analysis to test for association between <jats:italic>COMT<\/jats:italic> and five psychosis symptom scales. These were derived through factor analysis of the Operational Criteria Checklist for Psychiatric Illness. Our sample was the Irish Study of High Density Schizophrenia Families, a large collection consisting of 268 multiplex families. This sample has previously shown a small but significant effect of the <jats:italic>COMT<\/jats:italic> Val allele in conferring risk for schizophrenia. We tested for preferential transmission of <jats:italic>COMT<\/jats:italic> alleles from parent to affected offspring (n\u2009=\u2009749) for each of the five factor\u2010derived scales (negative symptoms, delusions, hallucinations, mania, and depression). Significant overtransmission of the Val allele was found for mania (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and depression (<jats:italic>P<\/jats:italic>\u2009=\u20090.01) scales. Examination of odds ratios (ORs) revealed a heterogeneous effect of <jats:italic>COMT<\/jats:italic>, whereby it had no effect on Negative Symptoms, but largest impact on Depression (OR\u2009=\u20091.4). These results suggest a modest affective vulnerability conferred by this allele in psychosis, but will require replication. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30401","type":"journal-article","created":{"date-parts":[[2006,8,18]],"date-time":"2006-08-18T17:13:41Z","timestamp":1155921221000},"page":"935-938","source":"Crossref","is-referenced-by-count":25,"title":["Catechol\u2010<i>O<\/i>\u2010methyltransferase and the clinical features of psychosis"],"prefix":"10.1002","volume":"141B","author":[{"given":"J.L.","family":"McClay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fanous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.J.C.G.","family":"van den 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