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This sequence encodes polyalanine and polyglycine stretches within the N\u2010terminal portion of MeCP2, and may confer novel functional properties to the protein. We screened autism, mental retardation (MR), and control populations for sequence variation within this region, and identified variation in \u223c1% of MR cases screened (N\u2009=\u20091,410). No variants were identified in the autism sample (N\u2009=\u2009401). Most of these variants occur within a trinucleotide repeat region and result in change in number of alanine or glycine residues within the repeat stretches. 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