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We have now genotyped an additional 12 short tandem repeats (STR) in this region. Multipoint analysis shows the region remains significant with an increase in the peak MLS from 2.9 to 3.8 at 95 cM near marker D9S1815, and the 1 LOD interval narrows from 21.5 to 11 cM. HLOD scores also provide evidence for significant linkage (4.5 with an \u03b1\u2009=\u200931%) with a further narrowing of the region to 6.6 cM (92.2\u201398.8 cM). Single nucleotide polymorphisms (SNPs) in the Ubiquilin1 gene (<jats:italic>UBQLN1<\/jats:italic>), located at 83.3 cM, have been reported to be significantly associated to AD, accounting for a substantial portion of the original linkage signal [Bertram et al., <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#bib6\">2005<\/jats:ext-link>]. Our analyses of the higher resolution genotype data generated here provide further support for the existence of a least one additional locus on chromosome 9q22. In an effort to pinpoint this putative AD susceptibility gene, we have begun to analyze SNPs in other candidate genes in and around this narrowed region to test for additional associations to AD. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30433","type":"journal-article","created":{"date-parts":[[2006,10,10]],"date-time":"2006-10-10T18:17:12Z","timestamp":1160504232000},"page":"220-227","source":"Crossref","is-referenced-by-count":8,"title":["Follow\u2010up mapping supports the evidence for linkage in the candidate region at 9q22 in the NIMH Alzheimer's disease Genetics Initiative cohort"],"prefix":"10.1002","volume":"144B","author":[{"given":"Rodney T.","family":"Perry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Wiener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindy 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