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A\u03b2 has been shown to mediate neurodegenerative and inflammatory changes associated with amyloid plaques, although the pathological mechanism of A\u03b2 remains largely unknown. Recent evidence suggests that the FISH adapter protein binds to, and potentially regulates, ADAM12 (a disintegrin and metalloprotease 12) to mediate a neurotoxic effect of A\u03b2. The <jats:italic>ADAM12<\/jats:italic> gene lies on chromosome 10q26.3, and the gene encoding FISH, <jats:italic>SH3MD1<\/jats:italic>, lies within a region of linkage to late\u2010onset AD (LOAD) on 10q25.1. This study investigates whether there is a relationship between variation in <jats:italic>ADAM12<\/jats:italic> and <jats:italic>SH3MD1<\/jats:italic> and susceptibility to LOAD in a sample of 1,051 AD cases and 1,269 matched controls. We observe significant interactions between variants in the two genes that may influence susceptibility to LOAD. The most significant statistical interaction is between rs3740473, a synonymous single nucleotide polymorphism (SNP) in <jats:italic>SH3MD1<\/jats:italic> and rs11244787, an intronic SNP in <jats:italic>ADAM12<\/jats:italic> (effect size\u2009=\u20092.1 for interaction term, <jats:italic>P<\/jats:italic>\u2009=\u20090.006). \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30456","type":"journal-article","created":{"date-parts":[[2007,4,17]],"date-time":"2007-04-17T16:48:29Z","timestamp":1176828509000},"page":"448-452","source":"Crossref","is-referenced-by-count":31,"title":["Interaction between the <i>ADAM12<\/i> and <i>SH3MD1<\/i> genes may confer susceptibility to late\u2010onset Alzheimer's 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