{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:25:40Z","timestamp":1792725940768,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T00:00:00Z","timestamp":1177027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2007,6,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dyslexia is a common heterogeneous disorder with a significant genetic component. Multiple studies have replicated the evidence for linkage between variously defined phenotypes of dyslexia and chromosomal regions on 15q21 (<jats:italic>DYX1<\/jats:italic>) and 6p22.2 (<jats:italic>DYX2<\/jats:italic>). Based on association studies and the possibility for functional significance of several polymorphisms, candidate genes responsible for the observed linkage signal have been proposed\u2014<jats:italic>DYX1C1<\/jats:italic> for 15q21, and <jats:italic>KIAA0319<\/jats:italic> and <jats:italic>DCDC2<\/jats:italic> for 6p22.2. We investigated the evidence for contribution of these candidate genes to dyslexia in our sample of multigenerational families. Our previous quantitative linkage analyses in this dataset provided supportive evidence for linkage of dyslexia to the locus on chromosome 15, but not to the locus on chromosome 6. In the current study, we used probands from 191 families for a case control analysis, and proband\u2010parent trios for family\u2010based TDT analyses. The observation of weak evidence for transmission disequilibrium for one of the two studied polymorphisms in <jats:italic>DYX1C1<\/jats:italic> suggests involvement of this gene in dyslexia in our dataset. We did not find evidence for the association of <jats:italic>KIAA0319<\/jats:italic> or <jats:italic>DCDC2<\/jats:italic> alleles to dyslexia in our sample. We observed a slight tendency for an intronic deletion in <jats:italic>DCDC2<\/jats:italic> to be associated with worse performance on some quantitative measures of dyslexia in the probands in our sample, but not in their parents. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30471","type":"journal-article","created":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T16:10:41Z","timestamp":1177085441000},"page":"556-560","source":"Crossref","is-referenced-by-count":74,"title":["Evaluation of candidate genes for <i>DYX1<\/i> and <i>DYX2<\/i> in families with dyslexia"],"prefix":"10.1002","volume":"144B","author":[{"given":"Zoran","family":"Brkanac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola H.","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark 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