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Reduced response to niacin flushing test, which involves vasodilatation induced by prostaglandin D2 (PGD2), is among the evidences, together with decreased CSF levels of lipocalin\u2010type prostaglandin D2 synthase (PTGDS), the enzyme responsible for the synthesis of PGD2 in the brain. Since PTGDS is also a carrier for lipophilic molecules such as retinoids and thyroid hormones, altered PTGDS levels might influence both PGD2\u2010mediated signaling, and vitamin A and thyroid hormone availability. To test whether genetic variants of<jats:italic>PTGDS<\/jats:italic>are involved in the etiology of schizophrenia, we searched for variants in the coding and regulatory regions of the gene. We identified four previously described polymorphisms. Using two case\u2010control samples from Portugal and Brazil, none of the polymorphisms tested was associated with the disease. In addition, no transmission distortion was observed in an independent parents\u2010offspring sample from the Azorean Islands. Our data do not support the involvement of the<jats:italic>PTGDS<\/jats:italic>gene in the etiology of schizophrenia. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30477","type":"journal-article","created":{"date-parts":[[2007,1,17]],"date-time":"2007-01-17T21:47:52Z","timestamp":1169070472000},"page":"642-646","source":"Crossref","is-referenced-by-count":4,"title":["Family\u2010based and case\u2010control studies reveal no association of<i>lipocalin\u2010type prostaglandin D2 synthase<\/i>with schizophrenia"],"prefix":"10.1002","volume":"144B","author":[{"given":"Dina","family":"Ruano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f3nio","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria 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