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In the present study, a meta\u2010analysis of six available case\u2010control studies (557 patients with panic disorder and 763 healthy controls in total) on the role of the COMT val158met polymorphism in panic disorder was conducted in an attempt to reconcile previous conflicting results and to facilitate evaluation of the role of COMT gene variation in panic disorder. Overall, no significant association, but strong between\u2010study heterogeneity, was discerned. Analysis of studies pooled by ancestry yielded a significant association of the COMT 158val allele with panic disorder in Caucasian samples and, conversely, a trend towards association of the COMT 158met allele with the disorder in Asian samples. Interestingly, stratification for gender as well as ethnicity revealed that association of the 158val allele in Caucasians and, reciprocally, the 158met allele in Asian samples was restricted to females. The present meta\u2010analysis provides tentative support for the COMT val158met polymorphism as a possible risk factor for panic disorder, with differential effects in Caucasian and Asian populations, and suggests a female\u2010specific effect. However, given the relatively small number of case\u2010control studies presently available, several more association studies, preferably including a larger number of family\u2010based studies, are warranted for conclusive evaluation of the COMT val158met polymorphism as a vulnerability factor in panic disorder. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30494","type":"journal-article","created":{"date-parts":[[2007,3,13]],"date-time":"2007-03-13T21:05:05Z","timestamp":1173819905000},"page":"667-673","source":"Crossref","is-referenced-by-count":126,"title":["Meta\u2010analysis of COMT val158met in panic disorder: Ethnic heterogeneity and gender 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