{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:27:54Z","timestamp":1790418474876,"version":"4.1.0"},"reference-count":81,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,5,17]],"date-time":"2007-05-17T00:00:00Z","timestamp":1179360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2007,12,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Impulsive\u2013aggressive behaviors (IABs) are regarded as possible suicide intermediate phenotypes, mediating the relationship between genes and suicide outcome. In this study, we aimed to investigate the putative relationship between genetic variation at the 5\u2010HT<jats:sub>1B<\/jats:sub> receptor gene, which in animal models is involved in impulse\u2010aggression control, IABs, and suicide risk. We investigated the relationship of variation at five 5\u2010HT<jats:sub>1B<\/jats:sub> loci and IAB measures in a sample of 696 subjects, including 338 individuals who died by suicide and 358 normal epidemiological controls. We found that variation at the 5\u2010HT<jats:sub>1B<\/jats:sub> promoter A\u2010161T locus had a significant effect on levels of IABs, as measured by the Buss\u2013Durkee Hostility Inventory (BDHI). Suicides also differed from controls in distribution of variants at this locus. The A\u2010161T locus, which seems to impact 5\u2010HT<jats:sub>1B<\/jats:sub> transcription, could play a role in suicide predisposition by means of mediating impulsive\u2013aggressive behaviors. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30521","type":"journal-article","created":{"date-parts":[[2007,5,26]],"date-time":"2007-05-26T22:56:02Z","timestamp":1180220162000},"page":"996-1002","source":"Crossref","is-referenced-by-count":64,"title":["The effect of genetic variation of the serotonin 1B receptor gene on impulsive aggressive behavior and suicide"],"prefix":"10.1002","volume":"144B","author":[{"given":"Hana","family":"Zouk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"McGirr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Lebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chawky","family":"Benkelfat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Rouleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Turecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,5,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.148.7.883"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3956(03)00048-7"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1976.01770100055005"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00010-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth457"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30044"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1996.01830120085015"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004583-199410000-00003"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1993.tb03341.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1986.tb27897.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1997.tb52356.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1993.tb03481.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0046900"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1473"},{"key":"e_1_2_6_16_1","first-page":"170","article-title":"The 5\u2010HT1B receptor: Behavioral implications","volume":"35","author":"Clark MS","year":"2001","journal-title":"Psychopharmacol Bull"},{"key":"e_1_2_6_17_1","volume-title":"The temperament and character inventory (TCI): A guide to its development and use","author":"Cloninger CR","year":"1994"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1192\/S0007125000291769","article-title":"Central serotonin and impulsive aggression","volume":"8","author":"Coccaro EF","year":"1989","journal-title":"Br J Psychiatry"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199206006-00008"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950040062008"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2001.00091.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2001.00405.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00019442-200401000-00005"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0996-98"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041444-200409000-00004"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1993.tb05368.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001403"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2004.11.028"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.11.2116"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.7.1375"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2003.12.005"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(00)00215-8"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001048"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1988.tb01176.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000075330"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(99)00030-5"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300000"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.56.9.805"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1996.tb09869.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.5.1017"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00283-4"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2006.03221.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320600214"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.55.11.989"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2005.11.016"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.151.7.1063"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/74215"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199204001-00004"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0198-025"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1220"},{"key":"e_1_2_6_51_1","article-title":"Risk factors for suicide completion in borderline personality disorder: A case\u2010control study of cluster B comorbidity and impulsive aggression","author":"McGirr A","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2006.02.025"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(92)91655-A"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00581-1"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00259-7"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01108-8"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1347"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.2792"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(95)00108-5"},{"key":"e_1_2_6_60_1","first-page":"1699","volume-title":"Neuropsychopharmacology: The 5th generation of progress","author":"Olivier B","year":"2002"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(199511)51:6<768::AID-JCLP2270510607>3.0.CO;2-1"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001244"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5281.1516"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/30259"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1988.tb06380.x"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.10732"},{"key":"e_1_2_6_67_1","volume-title":"Molecular Cloning. A Laboratory Manual","author":"Sambrook J","year":"1989"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2000.6411"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2004.08.008"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8091214"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(99)00013-X"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.20064"},{"key":"e_1_2_6_73_1","volume-title":"L'\u00e9pidemiologie du suicide au Qu\u00e9bec: Que savons\u2010nous de la situation r\u00e9cente","author":"St\u2010Laurent D","year":"2004"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.20174"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01366-X"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1159\/000079977"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2001.30608.x"},{"key":"e_1_2_6_78_1","first-page":"398","article-title":"Dissecting the suicide phenotype: The role of impulsive\u2013aggressive behaviours","volume":"30","author":"Turecki G","year":"2005","journal-title":"J Psychiatry Neurosci"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1027\/\/0227-5910.21.4.160"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0193-953X(05)70330-0"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.NMD.0000081613.03157.D9"},{"key":"e_1_2_6_82_1","doi-asserted-by":"crossref","first-page":"52S","DOI":"10.1038\/sj.npp.1395371","article-title":"Altered emotional states in knockout mice lacking 5\u2010HT1A or 5\u2010HT1B receptors","volume":"21","author":"Zhuang X","year":"1999","journal-title":"Neuropsychopharmacology"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.30521","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.30521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T05:35:35Z","timestamp":1697607335000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.30521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,17]]},"references-count":81,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,12,5]]}},"alternative-id":["10.1002\/ajmg.b.30521"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.30521","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,17]]}}}