{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:55:03Z","timestamp":1758477303480},"reference-count":63,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,4,23]],"date-time":"2007-04-23T00:00:00Z","timestamp":1177286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J of Med Genetics Pt B"],"published-print":{"date-parts":[[2007,9,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bipolar disorder (BPD) is a complex genetic disorder with cycling symptoms of depression and mania. Despite the extreme complexity of this psychiatric disorder, attempts to localize genes which confer vulnerability to the disorder have had some success. Chromosomal regions including 4p16, 12q24, 18p11, 18q22, and 21q21 have been repeatedly linked to BPD in different populations. Here we present the results of a whole genome scan for linkage to BPD in an Irish population. Our most significant result was at 14q24 which yielded a non\u2010parametric LOD (NPL) score of 3.27 at the D14S588 marker with a nominal <jats:italic>P<\/jats:italic>\u2010value of 0.0006 under a narrow (bipolar type I only) model of affection. We previously reported linkage to 14q22\u201024 in a subset of the families tested in this analysis. We also obtained suggestive evidence for linkage at 4q21, 9p21, 12q24, and 16p13, chromosomal regions that have all been previously linked to BPD. Additionally, we report on a novel approach to linkage analysis, STRUCTURE\u2010Guided Linkage Analysis (SGLA), which is designed to reduce genetic heterogeneity and increase the power to detect linkage. Application of this technique resulted in more highly significant evidence for linkage of BPD to three regions including 16p13, a locus that has been repeatedly linked to numerous psychiatric disorders. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ajmg.b.30524","type":"journal-article","created":{"date-parts":[[2007,4,23]],"date-time":"2007-04-23T17:22:08Z","timestamp":1177348928000},"page":"791-801","source":"Crossref","is-referenced-by-count":27,"title":["Genome\u2010wide scan of bipolar disorder and investigation of population stratification effects on linkage: Support for susceptibility loci at 4q21, 7q36, 9p21, 12q24, 14q24, and 16p13"],"prefix":"10.1002","volume":"144B","author":[{"given":"F.","family":"Cassidy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Badger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Claffey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Dobrin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Roche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"McKeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.3.571"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30303"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5618.2001.30603.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.296.5566.261b"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001778"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.25.2933"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201549"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.178.41.s128"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.164.3.355"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320600203"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000882"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990618)88:3<255::AID-AJMG8>3.0.CO;2-V"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.10.5604"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970531)74:3<254::AID-AJMG4>3.0.CO;2-Q"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1978.01770310043002"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001815"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041444-199800830-00002"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001074"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970919)74:5<549::AID-AJMG20>3.0.CO;2-B"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041444-199522000-00005"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/422474"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.11.1125"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1086\/318788"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1086\/342205"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-199307000-00004"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/35006158"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0111"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1086\/501072"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30192"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0327(02)00323-3"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1086\/301592"},{"key":"e_1_2_7_34_1","first-page":"1347","article-title":"Parametric and nonparametric linkage analysis: A unified multipoint approach","volume":"58","author":"Kruglyak L","year":"1996","journal-title":"Am J Hum Genet"},{"issue":"1","key":"e_1_2_7_35_1","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1002\/1098-2272(2000)19:1+<::AID-GEPI6>3.0.CO;2-M","article-title":"Implementing a unified approach to family\u2010based tests of association","volume":"19","author":"Laird NM","year":"2000","journal-title":"Genet Epidemiol"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001684"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1195-241"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1086\/376549"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001254"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001703"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30314"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001594"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1086\/424697"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2003.08.001"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001277"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1086\/491603"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20001204)96:6<728::AID-AJMG6>3.0.CO;2-9"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1086\/424387"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6750-4-15"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2004.02396.x"},{"key":"e_1_2_7_51_1","first-page":"155","article-title":"Genetic drift and anthropometric variation in Ireland","volume":"63","author":"Relethford JH","year":"1991","journal-title":"Hum Biol"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1078311"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.9.1621"},{"key":"e_1_2_7_54_1","first-page":"S80","article-title":"Bipolar disorder: Disease burden","volume":"11","author":"Sajatovic M","year":"2005","journal-title":"Am J Manag Care"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1086\/376547"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30165"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001601"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001041"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.12.2222"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30141"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1086\/507847"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000888"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2660(01)42016-5"},{"key":"e_1_2_7_64_1","first-page":"A1765","article-title":"Computer system for large scale STRP genotyping","volume":"61","author":"Zhao C","year":"1997","journal-title":"The 47th American Society of Human Genetics"}],"container-title":["American Journal of Medical Genetics Part B: Neuropsychiatric Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fajmg.b.30524","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ajmg.b.30524","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T13:40:03Z","timestamp":1696772403000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ajmg.b.30524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,20]]},"references-count":63,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,9,5]]}},"alternative-id":["10.1002\/ajmg.b.30524"],"URL":"https:\/\/doi.org\/10.1002\/ajmg.b.30524","archive":["Portico"],"relation":{},"ISSN":["1552-4841","1552-485X"],"issn-type":[{"value":"1552-4841","type":"print"},{"value":"1552-485X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,20]]}}}